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Rat Anti-NBL1 Recombinant Antibody (CBWJN-0845) (CBMAB-N1250-WJ)

This product is a Rat antibody that recognizes NBL1. The antibody CBWJN-0845 can be used for immunoassay techniques such as: WB.
See all NBL1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBWJN-0845
Antibody Isotype
IgG2
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuroblastoma 1, DAN Family BMP Antagonist
Introduction
This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]
Entrez Gene ID
17965
UniProt ID
Q61477
Alternative Names
Neuroblastoma 1, DAN Family BMP Antagonist; Neuroblastoma Candidate Region, Suppression Of Tumorigenicity 1; Differential Screening-Selected Gene Aberrant In Neuroblastoma; Neuroblastoma Suppressor Of Tumorigenicity 1; DAN Domain Family Member 1; DAND1; DAN;
Function
Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.
Biological Process
Animal organ morphogenesis Source: GO_Central
Determination of dorsal identity Source: BHF-UCL
Negative regulation of BMP signaling pathway Source: UniProtKB
Negative regulation of monocyte chemotaxis Source: BHF-UCL
Nervous system development Source: BHF-UCL
Neuron projection morphogenesis Source: BHF-UCL
Positive regulation of neuron differentiation Source: BHF-UCL
Sequestering of BMP from receptor via BMP binding Source: UniProtKB
Sequestering of BMP in extracellular matrix Source: BHF-UCL
Cellular Location
Secreted
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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