NBR1

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.
Full Name
NBR1, Autophagy Cargo Receptor
Alternative Names
NBR1, Autophagy Cargo Receptor; Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125); Cell Migration-Inducing Gene 19 Protein; Neighbor Of BRCA1 Gene 1; M17S2; Membrane Component Chromosome 17 Surface Marker 2; Neighbor Of BRCA1 Gene 1 Protein; Migration-Inducing Protein 19; Next To BRCA1 Gene 1 Protein;
Function
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
Biological Process
Macroautophagy Source: UniProtKB
Negative regulation of osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: BHF-UCL
Regulation of stress-activated MAPK cascade Source: BHF-UCL
Cellular Location
Cytoplasm
Lysosome
Other locations
autophagosome
M line
Note: In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911).
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Anti-NBR1 antibodies

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Rabbit Anti-NBR1 Recombinant Antibody (D2E6) (CBMAB-N1302-WJ)

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Target: NBR1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: D2E6
Application*: WB, IP, IF, F
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (
15E3) (V2LY-0725-LY391)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 15E3
Application*: E, IH
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (CBT937) (V2LY-0625-LY3168)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBT937
Application*: IF, IC, P
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (EC197) (V2LY-0624-LY197)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC197
Application*: P, IF
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (A1297) (CBMAB-AP4989LY)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1297
Application*: ELISA, IHC
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (A1296) (CBMAB-AP12532LY)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1296
Application*: IF, IHC
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (7C3) (CBMAB-N1301-WJ)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 7C3
Application*: P
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (6B11) (CBMAB-N1300-WJ)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6B11
Application*: E, WB
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (5C3) (CBMAB-N1299-WJ)

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Target: NBR1
Host: Mouse
Specificity: Human
Clone: 5C3
Application*: E, WB
Datasheet SDS

Mouse Anti-NBR1 Recombinant Antibody (2E7) (CBMAB-N1297-WJ)

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Target: NBR1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2E7
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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