NBR1

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants.

NBR1, Autophagy Cargo Receptor

NBR1, Autophagy Cargo Receptor; Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125); Cell Migration-Inducing Gene 19 Protein; Neighbor Of BRCA1 Gene 1; M17S2; Membrane Component Chromosome 17 Surface Marker 2; Neighbor Of BRCA1 Gene 1 Protein; Migration-Inducing Protein 19; Next To BRCA1 Gene 1 Protein;

Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.

Macroautophagy Source: UniProtKB
Negative regulation of osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: BHF-UCL
Regulation of stress-activated MAPK cascade Source: BHF-UCL

Cytoplasm
Lysosome
Other locations
autophagosome
M line
Note: In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911).