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Mouse Anti-NBR1 Recombinant Antibody (2E7) (CBMAB-N1297-WJ)

This product is a Mouse antibody that recognizes NBR1. The antibody 2E7 can be used for immunoassay techniques such as: ELISA, WB.
See all NBR1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2E7
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NBR1, Autophagy Cargo Receptor
Introduction
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Entrez Gene ID
4077
UniProt ID
Q14596
Alternative Names
NBR1, Autophagy Cargo Receptor; Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125); Cell Migration-Inducing Gene 19 Protein; Neighbor Of BRCA1 Gene 1; M17S2; Membrane Component Chromosome 17 Surface Marker 2; Neighbor Of BRCA1 Gene 1 Protein; Migration-Inducing Protein 19; Next To BRCA1 Gene 1 Protein;
Function
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
Biological Process
Macroautophagy Source: UniProtKB
Negative regulation of osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: BHF-UCL
Regulation of stress-activated MAPK cascade Source: BHF-UCL
Cellular Location
Cytoplasm
Lysosome
Other locations
autophagosome
M line
Note: In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911).

Zhang, J., Wang, Y. Y., Pan, Z. Q., Li, Y., Sui, J., Du, L. L., & Ye, K. (2022). Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1. Nature Communications, 13(1), 3650.

Adriaenssens, E., Ferrari, L., & Martens, S. (2022). Orchestration of selective autophagy by cargo receptors. Current Biology, 32(24), R1357-R1371.

Rasmussen, N. L., Kournoutis, A., Lamark, T., & Johansen, T. (2022). NBR1: The archetypal selective autophagy receptor. Journal of Cell Biology, 221(11), e202208092.

Zellner, S., Schifferer, M., & Behrends, C. (2021). Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling. Molecular cell, 81(6), 1337-1354.

Luo, S., Li, X., Zhang, Y., Fu, Y., Fan, B., Zhu, C., & Chen, Z. (2021). Cargo recognition and function of selective autophagy receptors in plants. International journal of molecular sciences, 22(3), 1013.

Wang, Y. Y., Zhang, J., Liu, X. M., Li, Y., Sui, J., Dong, M. Q., ... & Du, L. L. (2021). Molecular and structural mechanisms of ZZ domain‐mediated cargo selection by Nbr1. The EMBO Journal, 40(15), e107497.

Zhang, Y., & Chen, Z. (2020). Broad and complex roles of NBR1-mediated selective autophagy in plant stress responses. Cells, 9(12), 2562.

Jung, H., Lee, H. N., Marshall, R. S., Lomax, A. W., Yoon, M. J., Kim, J., ... & Chung, T. (2020). Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins. Journal of experimental botany, 71(1), 73-89.

Tarnowski, L., Rodriguez, M. C., Brzywczy, J., Piecho-Kabacik, M., Krčkova, Z., Martinec, J., ... & Sirko, A. (2020). A selective autophagy cargo receptor NBR1 modulates abscisic acid signalling in Arabidopsis thaliana. Scientific Reports, 10(1), 7778.

Tarnowski, L., Collados Rodriguez, M., Brzywczy, J., Cysewski, D., Wawrzynska, A., & Sirko, A. (2020). Overexpression of the selective autophagy cargo receptor NBR1 modifies plant response to sulfur deficit. Cells, 9(3), 669.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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