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Mouse Anti-NBR1 Recombinant Antibody (CBT937) (V2LY-0625-LY3168)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBT937
Antibody Isotype
IgG
Application
IF, ICC, IHC-P

Basic Information

Immunogen
Recombinant Protein of NBR1
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
IF1:50-1:200
IHC-P1:50-1:300

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, Glycerol, BSA
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NBR1, Autophagy Cargo Receptor
Entrez Gene ID
4077
UniProt ID
Q14596
Alternative Names
NBR1, Autophagy Cargo Receptor; Membrane Component, Chromosome 17, Surface Marker 2 (Ovarian Carcinoma Antigen CA125); Cell Migration-Inducing Gene 19 Protein; Neighbor Of BRCA1 Gene 1; M17S2; Membrane Component Chromosome 17 Surface Marker 2; Neighbor Of BRCA1 Gene 1 Protein; Migration-Inducing Protein 19; Next To BRCA1 Gene 1 Protein;
Function
Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets.
Biological Process
Macroautophagy Source: UniProtKB
Negative regulation of osteoblast differentiation Source: BHF-UCL
Regulation of bone mineralization Source: BHF-UCL
Regulation of stress-activated MAPK cascade Source: BHF-UCL
Cellular Location
Cytoplasm
Lysosome
Other locations
autophagosome
M line
Note: In cardiac muscles localizes to the sarcomeric M line (By similarity). Is targeted to lysosomes for degradation (PubMed:19250911).
More Infomation

Zhang, J., Wang, Y. Y., Pan, Z. Q., Li, Y., Sui, J., Du, L. L., & Ye, K. (2022). Structural mechanism of protein recognition by the FW domain of autophagy receptor Nbr1. Nature Communications, 13(1), 3650.

Adriaenssens, E., Ferrari, L., & Martens, S. (2022). Orchestration of selective autophagy by cargo receptors. Current Biology, 32(24), R1357-R1371.

Rasmussen, N. L., Kournoutis, A., Lamark, T., & Johansen, T. (2022). NBR1: The archetypal selective autophagy receptor. Journal of Cell Biology, 221(11), e202208092.

Zellner, S., Schifferer, M., & Behrends, C. (2021). Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling. Molecular cell, 81(6), 1337-1354.

Luo, S., Li, X., Zhang, Y., Fu, Y., Fan, B., Zhu, C., & Chen, Z. (2021). Cargo recognition and function of selective autophagy receptors in plants. International journal of molecular sciences, 22(3), 1013.

Wang, Y. Y., Zhang, J., Liu, X. M., Li, Y., Sui, J., Dong, M. Q., ... & Du, L. L. (2021). Molecular and structural mechanisms of ZZ domain‐mediated cargo selection by Nbr1. The EMBO Journal, 40(15), e107497.

Zhang, Y., & Chen, Z. (2020). Broad and complex roles of NBR1-mediated selective autophagy in plant stress responses. Cells, 9(12), 2562.

Jung, H., Lee, H. N., Marshall, R. S., Lomax, A. W., Yoon, M. J., Kim, J., ... & Chung, T. (2020). Arabidopsis cargo receptor NBR1 mediates selective autophagy of defective proteins. Journal of experimental botany, 71(1), 73-89.

Tarnowski, L., Rodriguez, M. C., Brzywczy, J., Piecho-Kabacik, M., Krčkova, Z., Martinec, J., ... & Sirko, A. (2020). A selective autophagy cargo receptor NBR1 modulates abscisic acid signalling in Arabidopsis thaliana. Scientific Reports, 10(1), 7778.

Tarnowski, L., Collados Rodriguez, M., Brzywczy, J., Cysewski, D., Wawrzynska, A., & Sirko, A. (2020). Overexpression of the selective autophagy cargo receptor NBR1 modifies plant response to sulfur deficit. Cells, 9(3), 669.

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For research use only. Not intended for any clinical use.

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