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NFKBIB

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Full Name
NFKB Inhibitor Beta
Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Biological Process
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytoplasmic sequestering of NF-kappaBManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory responseIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
PTM
Cytoplasm By Similarity
Nucleus

Anti-NFKBIB antibodies

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Mouse Anti-NFKBIB Recombinant Antibody (CBYY-I1691) (CBMAB-I2861-YY)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBYY-I1691
Application*: WB, IP, IF, E

Rabbit Anti-NFKBIB Recombinant Antibody (CBYY-I1660) (CBMAB-I2830-YY)

Datasheet SDS
Target: NFKBIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYY-I1660
Application*: WB, IP

Rat Anti-NFKBIB Recombinant Antibody (CBYY-I0722) (CBMAB-I1610-YY)

Datasheet SDS
Target: NFKBIB
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0722
Application*: WB

Mouse Anti-NFKBIB Recombinant Antibody (2B11) (CBMAB-N2309-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B11
Application*: E, WB

Mouse Anti-NFKBIB Recombinant Antibody (1G6) (CBMAB-N2308-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G6
Application*: E, IF, WB

Mouse Anti-NFKBIB Recombinant Antibody (1F3) (CBMAB-N2307-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Specificity: Human
Clone: 1F3
Application*: P

Mouse Anti-NFKBIB Recombinant Antibody (1B5) (CBMAB-N2306-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B5
Application*: E, P

Mouse Anti-NFKBIB Recombinant Antibody (CBWJN-0140) (CBMAB-N2305-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0140
Application*: E, WB

Mouse Anti-NFKBIB Recombinant Antibody (3E11) (CBMAB-N2304-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E11
Application*: E, WB

Mouse Anti-NFKBIB Recombinant Antibody (CBWJN-1381) (CBMAB-N2303-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1381
Application*: E

Mouse Anti-NFKBIB Recombinant Antibody (7B4) (CBMAB-N0336-WJ)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B4
Application*: WB, E

Mouse Anti-NFKBIB Recombinant Antibody (A1351) (CBMAB-AP5085LY)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1351
Application*: ELISA, IHC

Mouse Anti-NFKBIB Recombinant Antibody (A1350) (CBMAB-AP5084LY)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1350
Application*: ELISA, IHC

Mouse Anti-NFKBIB Recombinant Antibody (A1349) (CBMAB-AP10804LY)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1349
Application*: IHC

Mouse Anti-NFKBIB Recombinant Antibody (A1348) (CBMAB-AP10795LY)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1348
Application*: IF, IHC

Mouse Anti-NFKBIB Recombinant Antibody (CB270A) (CBMAB-CA270LY)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB270A
Application*: ELISA, IHC

Mouse Anti-NFKBIB Recombinant Antibody (CB269A) (CBMAB-CA269LY)

Datasheet SDS
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB269A
Application*: ELISA, IHC

Rabbit Anti-NFKBIB Recombinant Antibody (D2O1T) (CBMAB-CP1131-LY)

Datasheet SDS
Target: NFKBIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: D2O1T
Application*: WB, IP

NFKBIB Matched Antibody Pair (797) (APMAB-797LY)

Datasheet SDS
Target: NFKBIB
Specificity: Human

NFKBIB Matched Antibody Pair (796) (APMAB-796LY)

Datasheet SDS
Target: NFKBIB
Specificity: Human
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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