NFKBIB
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.
Full Name
NFKB Inhibitor Beta
Alternative Names
NFKB Inhibitor Beta; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta; Thyroid Receptor-Interacting Protein 9; NF-Kappa-B Inhibitor Beta; TR-Interacting Protein 9; I-Kappa-B-Beta; NF-Kappa-BIB;
Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Biological Process
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytoplasmic sequestering of NF-kappaBManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory responseIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cytoplasmic sequestering of NF-kappaBManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory responseIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
Nucleus
PTM
Cytoplasm By Similarity
Nucleus
Nucleus
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Anti-NFKBIB antibodies
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CompareTarget: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB270A
Application*: ELISA, IHC
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3E11
Application*: E, WB
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC199
Application*: P
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1351
Application*: ELISA, IHC
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1350
Application*: ELISA, IHC
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1349
Application*: IHC
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A1348
Application*: IF, IHC
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB269A
Application*: ELISA, IHC
Target: NFKBIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: D2O1T
Application*: WB, IP
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2B11
Application*: E, WB
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G6
Application*: E, IF, WB
Target: NFKBIB
Host: Mouse
Specificity: Human
Clone: 1F3
Application*: P
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B5
Application*: E, P
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-0140
Application*: E, WB
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJN-1381
Application*: E
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7B4
Application*: WB, E
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBT790
Application*: P, IF, IC
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat, Mouse
Clone: CBT791
Application*: P, IF
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT793
Application*: WB, E
Target: NFKBIB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2807
Application*: WB
Target: NFKBIB
Specificity: Human
Target: NFKBIB
Specificity: Human
Target: NFKBIB
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: CBYY-I1691
Application*: WB, IP, IF, E
Target: NFKBIB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBYY-I1660
Application*: WB, IP
Target: NFKBIB
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0722
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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