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Mouse Anti-NFKBIB Recombinant Antibody (CB270A) (CBMAB-CA270LY)

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Basic Information

Host Animal
Mouse
Clone
CB270A
Application
ELISA, IHC
Immunogen
Recombinant Protein
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol, 0.5% BSA
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
NFKB Inhibitor Beta
Introduction
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Entrez Gene ID
Human4793
Mouse18036
Rat81525
UniProt ID
HumanQ15653
MouseQ60778
RatQ9JIA3
Alternative Names
NFKB Inhibitor Beta; Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer In B-Cells Inhibitor, Beta; Thyroid Receptor-Interacting Protein 9; NF-Kappa-B Inhibitor Beta; TR-Interacting Protein 9; I-Kappa-B-Beta; NF-Kappa-BIB;
Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Biological Process
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytoplasmic sequestering of NF-kappaBManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory responseIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
PTM
Cytoplasm By Similarity
Nucleus

Li, W., Maimaijiang, A., Wang, Y., Maimaitijiang, G., Lu, H., Zheng, S., & Liu, H. (2023). The MYCN/miR-20a-5p/NFKBIB/NF-κB signaling axis promotes the proliferation, invasion and migration of neuroblastoma.

Hsueh, Y. S., Chang, H. H., Shan, Y. S., Sun, H. S., Fletcher, J. A., Li, C. F., & Chen, L. T. (2019). Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors. Oncogene, 38(38), 6550-6565.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

NFKBIB Matched Antibody Pair (796) (CAT#: APMAB-796LY)

NFKBIB Matched Antibody Pair (797) (CAT#: APMAB-797LY)

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NFKBIB Matched Antibody Pair (797) (CAT#: APMAB-797LY)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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