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Rabbit Anti-NFKBIB Recombinant Antibody (D2O1T) (CBMAB-CP1131-LY)

The product is antibody recognizes NFKBIB. The antibody D2O1T immunoassay techniques such as: WB,IP.
See all NFKBIB antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat
Clone
D2O1T
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Arg155 of mouse IκBβ protein.
Specificity
Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NFKB Inhibitor Beta
Introduction
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]
Entrez Gene ID
Mouse18036
Rat81525
UniProt ID
MouseQ60778
RatQ9JIA3
Alternative Names
I(Kappa)B(beta); I-kappa-B-beta; IKB-beta; IKappaBbeta; IkB; IkBb; NF-kappa-BIB; ikB-B
Function
Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
Biological Process
Cellular response to lipopolysaccharideManual Assertion Based On ExperimentIBA:GO_Central
Cytoplasmic sequestering of NF-kappaBManual Assertion Based On ExperimentIBA:GO_Central
Inflammatory responseIEA:Ensembl
Regulation of I-kappaB kinase/NF-kappaB signalingIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Transcription, DNA-templatedManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Nucleus
PTM
Cytoplasm By Similarity
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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