NFYB

The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq]
Full Name
NFYB
Function
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Histone H3-K4 trimethylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Regulation of histone acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
PTM
Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.
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Anti-NFYB antibodies

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Mouse Anti-NFYB Recombinant Antibody (G-2) (CBMAB-N2335-WJ)

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Target: NFYB
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: G-2
Application*: WB, IP, IF, P, E
Datasheet SDS

Mouse Anti-NFYB Recombinant Antibody (CBWJN-1388) (CBMAB-N2334-WJ)

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Target: NFYB
Host: Mouse
Specificity: Human
Clone: CBWJN-1388
Application*: WB
Datasheet SDS

Mouse Anti-NFYB Recombinant Antibody (5D1) (CBMAB-N2332-WJ)

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Target: NFYB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5D1
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-NFYB Recombinant Antibody (2H2) (CBMAB-N2331-WJ)

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Target: NFYB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H2
Application*: E, WB
Datasheet SDS

Mouse Anti-NFYB Recombinant Antibody (6E4) (CBMAB-N2329-WJ)

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Target: NFYB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6E4
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-NFYB Recombinant Antibody (NFYBA7) (CBMAB-N0339-WJ)

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Target: NFYB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NFYBA7
Application*: DB, IC, IF, WB
Datasheet SDS

Mouse Anti-NFYB Antibody (V2-4983) (CBMAB-0731-YC)

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Target: NFYB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: V2-4983
Application*: IP, M
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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