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Mouse Anti-NFYB Antibody (V2-4983) (CBMAB-0731-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
V2-4983
Antibody Isotype
IgG2b
Application
IP, MA

Basic Information

Immunogen
Recombinant peptide
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NFYB
Introduction
NFYB (nuclear transcription factor Y, subunit beta) is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. NFYB forms a tight dimer with the C subunit, a prerequisite for subunit A association and the trimer binds to DNA with high specificity and affinity.
Entrez Gene ID
4801
UniProt ID
P25208
Alternative Names
CBF-A; HAP3; NF-YB
Function
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Histone H3-K4 trimethylationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:ARUK-UCL
Regulation of histone acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
PTM
Monoubiquitination at Lys-140 plays an important role in transcriptional activation by allowing the deposition of histone H3 methylations as well as histone H2B monoubiquitination at 'Lys-121'.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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