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NUMB

The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Full Name
NUMB, Endocytic Adaptor Protein
Function
Regulates clathrin-mediated receptor endocytosis (PubMed:18657069).
Plays a role in the process of neurogenesis (By similarity).
Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity).
Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity).
May also mediate local repair of brain ventricular wall damage (By similarity).
Biological Process
Adherens junction organizationIEA:Ensembl
AxonogenesisIEA:Ensembl
Lateral ventricle developmentISS:UniProtKB
Negative regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Neuroblast division in subventricular zoneISS:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neurogenesisISS:UniProtKB
Regulation of postsynaptic neurotransmitter receptor internalizationIEA:Ensembl
Cellular Location
Cell membrane
Endosome membrane
Localizes to perinuclear endosomes in an AAK1-dependent manner.
PTM
Phosphorylated on Ser-276 and Ser-295 by CaMK1.
Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity).
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.

Anti-NUMB antibodies

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Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Mouse, Human
Clone: Cmnb-1
Application*: IF, WB
Target: NUMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: T.873.4
Application*: F, IC, IF, IP, WB
Target: NUMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: S.925.4
Application*: F, IC, IF, IP, WB
Target: NUMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Frog, Zebrafish, Cattle, Horse
Clone: D5C2
Application*: WB, IF
Target: NUMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: C29G11
Application*: F, IF, IP, WB
Target: NUMB
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: CBWJN-0488
Application*: F, IF, IP, WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 6B2
Application*: F, WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5F6E1
Application*: E, WB, IH
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5A9
Application*: WB, IH
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4D3
Application*: WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4D10
Application*: WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 4C6
Application*: WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0407
Application*: E, WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H8
Application*: WB, IH
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B2
Application*: WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: 2G12B7
Application*: E, WB, IH, IF
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C4
Application*: F, WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2B9
Application*: WB, IH
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B5
Application*: WB, IH
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A7
Application*: WB, F, IF
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1A12
Application*: WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1A11
Application*: WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E8
Application*: P, WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1614
Application*: WB, IC
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Human
Clone: 3E5
Application*: WB, IH
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1613
Application*: IC, WB
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1E3
Application*: WB
Target: NUMB
Host: Mouse
Specificity: Mouse, Rat, Human, Dog
Clone: CBWJN-1612
Application*: WB, IF
Target: NUMB
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CF318
Application*: ELISA, WB, IHC, IF
Target: NUMB
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4A7-A6
Application*: WB, E
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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