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Mouse Anti-NUMB Recombinant Antibody (4A7-A6) (CBMAB-A6184-LY)

The product is antibody recognizes NUMB. The antibody 4A7-A6 immunoassay techniques such as: WB, ELISA.
See all NUMB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A7-A6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
NUMB (AAH33824, 1 a.a. ~ 135 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
NUMB, Endocytic Adaptor Protein
Introduction
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Entrez Gene ID
8650
UniProt ID
P49757
Alternative Names
S171
Function
Regulates clathrin-mediated receptor endocytosis (PubMed:18657069).
Plays a role in the process of neurogenesis (By similarity).
Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity).
Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity).
May also mediate local repair of brain ventricular wall damage (By similarity).
Biological Process
Adherens junction organizationIEA:Ensembl
AxonogenesisIEA:Ensembl
Lateral ventricle developmentISS:UniProtKB
Negative regulation of protein localization to plasma membraneManual Assertion Based On ExperimentIMP:UniProtKB
Neuroblast division in subventricular zoneISS:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neurogenesisISS:UniProtKB
Regulation of postsynaptic neurotransmitter receptor internalizationIEA:Ensembl
Cellular Location
Cell membrane
Endosome membrane
Localizes to perinuclear endosomes in an AAK1-dependent manner.
PTM
Phosphorylated on Ser-276 and Ser-295 by CaMK1.
Isoform 1 and isoform 2 are ubiquitinated by LNX leading to their subsequent proteasomal degradation (By similarity).
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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