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ODC1

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]

Full Name

Ornithine Decarboxylase 1

Function

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Biological Process

Kidney developmentIEA:Ensembl
Polyamine metabolic processTAS:Reactome
Positive regulation of cell population proliferationIEA:Ensembl
Putrescine biosynthetic process from ornithineISS:UniProtKB
Regulation of protein catabolic processISS:UniProtKB
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB

Cellular Location

cytoplasm
cytosol

Involvement in disease

Bachmann-Bupp syndrome (BABS):
An autosomal dominant disorder characterized by global developmental delay, alopecia, absolute or relative macrocephaly, and facial dysmorphism. Neuroimaging shows white matter abnormalities, prominent Virchow-Robin spaces, periventricular cysts, and abnormalities of the corpus callosum.

PTM

S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.

Anti-ODC1 antibodies

Mouse Anti-ODC1 Antibody (9BA25) (CBMAB-1472CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9BA25

Application*: E, WB

Mouse Anti-ODC1 Antibody (9BA24) (CBMAB-1471CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9BA24

Application*: P, IH, M

Mouse Anti-ODC1 Antibody (9BA23) (CBMAB-1470CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9BA23

Application*: E, WB

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0029) (CBMAB-O0312-CQ)

SDS

Target: ODC1

Host: Mouse

Specificity: Rat

Clone: CBXO-0029

Application*: WB, IC, P, C, E

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0028) (CBMAB-O0311-CQ)

SDS

Target: ODC1

Host: Mouse

Specificity: Human

Clone: CBXO-0028

Application*: WB, IC, P, C, E

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0027) (CBMAB-O0310-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBXO-0027

Application*: P, IP, WB

Mouse Anti-ODC1 Recombinant Antibody (2G5) (CBMAB-O0309-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 2G5

Application*: E, IF, IP, WB

Mouse Anti-ODC1 (AA 1-462) Recombinant Antibody (CBXO-0025) (CBMAB-O0308-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBXO-0025

Application*: E, WB

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0200) (CBMAB-O0307-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBXO-0200

Application*: IH, IP, WB

Mouse Anti-ODC1 Recombinant Antibody (1G6) (CBMAB-O0306-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey

Clone: 1G6

Application*: F, IF, WB

Mouse Anti-ODC1 Recombinant Antibody (1G1) (CBMAB-O0305-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1G1

Application*: F, IF, WB

Mouse Anti-ODC1 Recombinant Antibody (3F293) (CBMAB-O0304-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 3F293

Application*: C

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0026) (CBMAB-O0130-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Rat

Clone: CBXO-0026

Application*: IH

Mouse Anti-ODC1 Recombinant Antibody (ODC-22) (CBMAB-O0089-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: ODC-22

Application*: E, IH, WB

Mouse Anti-ODC1 Recombinant Antibody (ORN255-1) (CBMAB-O0085-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: ORN255-1

Application*: F, IF, P, WB

Mouse Anti-ODC1 Recombinant Antibody (ODC1/486) (CBMAB-O0060-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: ODC1/486

Application*: WB, F, P, IF, MC

Mouse Anti-ODC1 Recombinant Antibody (SPM565) (CBMAB-O0054-CQ)

SDS

Target: ODC1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Rat

Clone: SPM565

Application*: WB, F, E, IF, IP, P, C, MC

ODC1 Matched Antibody Pair (830) (APMAB-830LY)

SDS

Target: ODC1

Specificity: Human

ODC1 Matched Antibody Pair (829) (APMAB-829LY)

SDS

Target: ODC1

Specificity: Human

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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