ODC1

This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
Full Name
Ornithine Decarboxylase 1
Function
Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.
Biological Process
Kidney developmentIEA:Ensembl
Polyamine metabolic processTAS:Reactome
Positive regulation of cell population proliferationIEA:Ensembl
Putrescine biosynthetic process from ornithineISS:UniProtKB
Regulation of protein catabolic processISS:UniProtKB
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB
Cellular Location
cytoplasm
cytosol
Involvement in disease
Bachmann-Bupp syndrome (BABS):
An autosomal dominant disorder characterized by global developmental delay, alopecia, absolute or relative macrocephaly, and facial dysmorphism. Neuroimaging shows white matter abnormalities, prominent Virchow-Robin spaces, periventricular cysts, and abnormalities of the corpus callosum.
PTM
S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.
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Anti-ODC1 antibodies

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Mouse Anti-ODC1 Recombinant Antibody (CBXO-0028) (CBMAB-O0311-CQ)

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Target: ODC1
Host: Mouse
Specificity: Human
Clone: CBXO-0028
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0029) (CBMAB-O0312-CQ)

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Target: ODC1
Host: Mouse
Specificity: Rat
Clone: CBXO-0029
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0027) (CBMAB-O0310-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXO-0027
Application*: P, IP, WB
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (2G5) (CBMAB-O0309-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2G5
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-ODC1 (AA 1-462) Recombinant Antibody (CBXO-0025) (CBMAB-O0308-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXO-0025
Application*: E, WB
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0200) (CBMAB-O0307-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXO-0200
Application*: IH, IP, WB
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (1G6) (CBMAB-O0306-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: 1G6
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (1G1) (CBMAB-O0305-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1G1
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (3F293) (CBMAB-O0304-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 3F293
Application*: C
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0026) (CBMAB-O0130-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBXO-0026
Application*: IH
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (ODC-22) (CBMAB-O0089-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: ODC-22
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (ORN255-1) (CBMAB-O0085-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ORN255-1
Application*: F, IF, P, WB
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (ODC1/486) (CBMAB-O0060-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Rat
Clone: ODC1/486
Application*: WB, F, P, IF, MC
Datasheet SDS

Mouse Anti-ODC1 Recombinant Antibody (SPM565) (CBMAB-O0054-CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: SPM565
Application*: WB, F, E, IF, IP, P, C, MC
Datasheet SDS

Mouse Anti-ODC1 Antibody (9BA25) (CBMAB-1472CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9BA25
Application*: E, WB
Datasheet SDS

Mouse Anti-ODC1 Antibody (9BA24) (CBMAB-1471CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9BA24
Application*: P, IH, M
Datasheet SDS

Mouse Anti-ODC1 Antibody (9BA23) (CBMAB-1470CQ)

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Target: ODC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9BA23
Application*: E, WB
Datasheet SDS

ODC1 Matched Antibody Pair (830) (APMAB-830LY)

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Target: ODC1
Specificity: Human
Datasheet SDS

ODC1 Matched Antibody Pair (829) (APMAB-829LY)

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Target: ODC1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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