Mouse Odc1 ELISA Kit (V2LY-0626-LY1485)

Name: Mouse Odc1 ELISA Kit
SKU: V2LY-0626-LY1485
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.14 ng/mL

Detection Range

0.2-60 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Mouse

Assay Type

Sandwich

Reactivity

Mouse

Assay Time

1.5 h

Molecule Mass

51.2 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Ornithine Decarboxylase 1

Function

Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.

Biological Process

Kidney developmentIEA:Ensembl
Polyamine metabolic processTAS:Reactome
Positive regulation of cell population proliferationIEA:Ensembl
Putrescine biosynthetic process from ornithineISS:UniProtKB
Regulation of protein catabolic processISS:UniProtKB
Response to virusManual Assertion Based On ExperimentIEP:UniProtKB

Cellular Location

cytoplasm
cytosol

Involvement in disease

Bachmann-Bupp syndrome (BABS):
An autosomal dominant disorder characterized by global developmental delay, alopecia, absolute or relative macrocephaly, and facial dysmorphism. Neuroimaging shows white matter abnormalities, prominent Virchow-Robin spaces, periventricular cysts, and abnormalities of the corpus callosum.

PTM

S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues.

Pérez-Rodríguez, F., Valdés-Santiago, L., García-Chávez, J. N., Castro-Guillén, J. L., & Ruiz-Herrera, J. (2023). Analysis of gene expression related to polyamine concentration and dimorphism induced in ornithine decarboxylase (odc) and spermidine synthase (spd) Ustilago maydis mutants. Fungal Genetics and Biology, 166, 103792.

Peng, V., Cao, S., Trsan, T., Bando, J. K., Avila-Pacheco, J., Cleveland, J. L., ... & Colonna, M. (2022). Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription. Proceedings of the National Academy of Sciences, 119(45), e2214900119.

Miller, A. K., Tavera, G., Dominguez, R. L., Camargo, M. C., Waterboer, T., Wilson, K. T., ... & Morgan, D. R. (2021). Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus. Oncogene, 40(40), 5963-5969.

Zeng, Z., Lan, J., Lei, S., Yang, Y., He, Z., Xue, Y., & Chen, T. (2020). Simultaneous inhibition of ornithine decarboxylase 1 and pyruvate kinase M2 exerts synergistic effects against hepatocellular carcinoma cells. OncoTargets and therapy, 11697-11709.

Leon, K. E., Fruin, A. M., Nowotarski, S. L., & DiAngelo, J. R. (2020). The regulation of triglyceride storage by ornithine decarboxylase (Odc1) in Drosophila. Biochemical and Biophysical Research Communications, 523(2), 429-433.

Chai, X., Zhan, J., Pan, J., He, M., Li, B., Wang, J., ... & Liu, S. (2020). The rational discovery of multipurpose inhibitors of the ornithine decarboxylase. The FASEB Journal, 34(9), 10907-12921.

Hsieh, J. Y., Liu, Y. C., Cheng, I. T., Lee, C. J., Wang, Y. H., Fang, Y. S., ... & Hung, H. C. (2019). Critical factors in human antizymes that determine the differential binding, inhibition, and degradation of human ornithine decarboxylase. Biomolecules, 9(12), 864.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human ODC1 ELISA Kit (CAT#: V2LY-0626-LY1191)

Rat Odc1 ELISA Kit (CAT#: V2LY-0626-LY1293)

ODC1 Matched Antibody Pair (829) (CAT#: APMAB-829LY)

ODC1 Matched Antibody Pair (830) (CAT#: APMAB-830LY)

Antibody Pairs

ODC1 Matched Antibody Pair (829) (CAT#: APMAB-829LY)

ODC1 Matched Antibody Pair (830) (CAT#: APMAB-830LY)

Related Products

Human ODC1 ELISA Kit (CAT#: V2LY-0626-LY1191)

Mouse Anti-ODC1 Recombinant Antibody (3F293) (CAT#: CBMAB-O0304-CQ)

Mouse Anti-ODC1 Recombinant Antibody (SPM565) (CAT#: CBMAB-O0054-CQ)

Mouse Anti-ODC1 Recombinant Antibody (1G1) (CAT#: CBMAB-O0305-CQ)

Mouse Anti-ODC1 Antibody (9BA25) (CAT#: CBMAB-1472CQ)

ODC1 Matched Antibody Pair (829) (CAT#: APMAB-829LY)

Mouse Anti-ODC1 Recombinant Antibody (ODC-22) (CAT#: CBMAB-O0089-CQ)

Mouse Anti-ODC1 Recombinant Antibody (2G5) (CAT#: CBMAB-O0309-CQ)

Mouse Anti-ODC1 Recombinant Antibody (ODC1/486) (CAT#: CBMAB-O0060-CQ)

Mouse Anti-ODC1 Recombinant Antibody (CBXO-0028) (CAT#: CBMAB-O0311-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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