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ODC1 Matched Antibody Pair (829) (APMAB-829LY)

This antibody pair set can be used for detecting and quantifying protein level of human ODC1.
See all ODC1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Mouse anti-ODC1 monoclonal antibody, 100 ug
Detection Antibody
Anti-ODC1 Rabbit polyclonal antibody, 50 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2013]
Alternative Names
Ornithine Decarboxylase 1; EC 4.1.1.17; ODC; Ornithine Decarboxylase;
Entrez Gene ID
4953
UniProt ID
P11926

Pérez-Rodríguez, F., Valdés-Santiago, L., García-Chávez, J. N., Castro-Guillén, J. L., & Ruiz-Herrera, J. (2023). Analysis of gene expression related to polyamine concentration and dimorphism induced in ornithine decarboxylase (odc) and spermidine synthase (spd) Ustilago maydis mutants. Fungal Genetics and Biology, 166, 103792.

Peng, V., Cao, S., Trsan, T., Bando, J. K., Avila-Pacheco, J., Cleveland, J. L., ... & Colonna, M. (2022). Ornithine decarboxylase supports ILC3 responses in infectious and autoimmune colitis through positive regulation of IL-22 transcription. Proceedings of the National Academy of Sciences, 119(45), e2214900119.

Miller, A. K., Tavera, G., Dominguez, R. L., Camargo, M. C., Waterboer, T., Wilson, K. T., ... & Morgan, D. R. (2021). Ornithine decarboxylase (ODC1) gene variant (rs2302615) is associated with gastric cancer independently of Helicobacter pylori CagA serostatus. Oncogene, 40(40), 5963-5969.

Zeng, Z., Lan, J., Lei, S., Yang, Y., He, Z., Xue, Y., & Chen, T. (2020). Simultaneous inhibition of ornithine decarboxylase 1 and pyruvate kinase M2 exerts synergistic effects against hepatocellular carcinoma cells. OncoTargets and therapy, 11697-11709.

Leon, K. E., Fruin, A. M., Nowotarski, S. L., & DiAngelo, J. R. (2020). The regulation of triglyceride storage by ornithine decarboxylase (Odc1) in Drosophila. Biochemical and Biophysical Research Communications, 523(2), 429-433.

Chai, X., Zhan, J., Pan, J., He, M., Li, B., Wang, J., ... & Liu, S. (2020). The rational discovery of multipurpose inhibitors of the ornithine decarboxylase. The FASEB Journal, 34(9), 10907-12921.

Hsieh, J. Y., Liu, Y. C., Cheng, I. T., Lee, C. J., Wang, Y. H., Fang, Y. S., ... & Hung, H. C. (2019). Critical factors in human antizymes that determine the differential binding, inhibition, and degradation of human ornithine decarboxylase. Biomolecules, 9(12), 864.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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