OLFM4

This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Full Name
Olfactomedin 4
Function
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Biological Process
Cell adhesionIEA:UniProtKB-KW
Positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space
Mitochondrion
Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901).
PTM
N-glycosylated.
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Anti-OLFM4 antibodies

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Mouse Anti-OLFM4 Recombinant Antibody (CBXO-0214) (CBMAB-O0003-CQ)

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Target: OLFM4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0214
Application*: E, F, IF, IF
Datasheet SDS

Mouse Anti-OLFM4 Recombinant Antibody (CBXO-0056) (CBMAB-O0406-CQ)

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Target: OLFM4
Host: Mouse
Specificity: Human
Clone: CBXO-0056
Application*: WB, IC, P, C, E
Datasheet SDS

Rabbit Anti-OLFM4 Recombinant Antibody (CBXO-0045) (CBMAB-O0361-CQ)

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Target: OLFM4
Host: Rabbit
Specificity: Mouse
Clone: CBXO-0045
Application*: WB, IP, P, IF
Datasheet SDS

Rabbit Anti-OLFM4 Recombinant Antibody (CBXO-0423) (CBMAB-O0360-CQ)

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Target: OLFM4
Host: Rabbit
Specificity: Human
Clone: CBXO-0423
Application*: WB, P
Datasheet SDS

Mouse Anti-OLFM4 (AA 21-510) Recombinant Antibody (CBXO-0397) (CBMAB-O0359-CQ)

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Target: OLFM4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXO-0397
Application*: WB
Datasheet SDS

Human Recombinant OLFM4 protein, His Tag (V2LY-0526-LY5869)

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Target: OLFM4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-510
Tag: His Tag
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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