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Rabbit Anti-OLFM4 Recombinant Antibody (CBXO-0045) (CBMAB-O0361-CQ)

This product is a rabbit antibody that recognizes OLFM4. The antibody CBXO-0045 can be used for immunoassay techniques such as: WB, IP, IHC-P, IF.
See all OLFM4 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBXO-0045
Application
WB, IP, IHC-P, IF

Basic Information

Specificity
Mouse
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Olfactomedin 4
Introduction
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion.
Entrez Gene ID
380924
UniProt ID
Q6UX06
Alternative Names
Olfactomedin 4; G-CSF-Stimulated Clone 1 Protein; Antiapoptotic Protein GW112; GW112; HGC-1; HOLfD; OLM4
Function
May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.
Biological Process
Cell adhesionIEA:UniProtKB-KW
Positive regulation of substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIDA:UniProtKB
Signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Secreted, extracellular space
Mitochondrion
Subcellular location is not clearly defined: has been shown to be secreted (PubMed:16566923), but also in the mitochondrion (PubMed:15059901 and PubMed:20724538), cytoplasm and plasma membrane (PubMed:20724538) and in the nucleus (PubMed:15059901).
PTM
N-glycosylated.

Xu, K., Zheng, P., Zhao, S., Wang, J., Feng, J., Ren, Y., ... & Xie, P. (2023). LRFN5 and OLFM4 as novel potential biomarkers for major depressive disorder: a pilot study. Translational Psychiatry, 13(1), 188.

Liu, W., Li, H., Aerbajinai, W., Botos, I., & Rodgers, G. P. (2022). OLFM4-RET fusion is an oncogenic driver in small intestine adenocarcinoma. Oncogene, 41(1), 72-82.

Ren, X., Geng, M., Xu, K., Lu, C., Cheng, Y., Kong, L., ... & Xu, P. (2021). Quantitative proteomic analysis of synovial tissue reveals that upregulated OLFM4 aggravates inflammation in rheumatoid arthritis. Journal of proteome research, 20(10), 4746-4757.

Gong, F., Li, R., Zheng, X., Chen, W., Zheng, Y., Yang, Z., ... & Chen, E. (2021). OLFM4 regulates lung epithelial cell function in sepsis-associated ARDS/ALI via LDHA-mediated NF-κB signaling. Journal of inflammation research, 7035-7051.

Gao, X. Z., Wang, G. N., Zhao, W. G., Han, J., Diao, C. Y., Wang, X. H., ... & Li, W. C. (2019). Blocking OLFM4/HIF‐1α axis alleviates hypoxia‐induced invasion, epithelial–mesenchymal transition, and chemotherapy resistance in non‐small‐cell lung cancer. Journal of Cellular Physiology, 234(9), 15035-15043.

Valo, I., Raro, P., Boissard, A., Maarouf, A., Jézéquel, P., Verriele, V., ... & Guette, C. (2019). OLFM4 Expression in Ductal Carcinoma In Situ and in Invasive Breast Cancer Cohorts by a SWATH‐Based Proteomic Approach. Proteomics, 19(21-22), 1800446.

Fu, J., Dong, G., Shi, H., Zhang, J., Ning, Z., Bao, X., ... & Xiong, B. (2019). LncRNA MIR503HG inhibits cell migration and invasion via miR‐103/OLFM4 axis in triple negative breast cancer. Journal of cellular and molecular medicine, 23(7), 4738-4745.

Ashizawa, Y., Kuboki, S., Nojima, H., Yoshitomi, H., Furukawa, K., Takayashiki, T., ... & Ohtsuka, M. (2019). OLFM4 enhances STAT3 activation and promotes tumor progression by inhibiting GRIM19 expression in human hepatocellular carcinoma. Hepatology Communications, 3(7), 954-970.

Li, J., Liu, C., Li, D., Wan, M., Zhang, H., Zheng, X., ... & Sun, Q. (2019). OLFM4 inhibits epithelial–mesenchymal transition and metastatic potential of cervical cancer cells. Oncology Research, 27(7), 763.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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