OTUD6B

Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA5 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM

Full Name

OTUD6B

Function

Isoform 1
Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334).
May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334).
May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334).
May also play a role in proteasome assembly and function (PubMed:28343629).
Isoform 2
Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.

Biological Process

Cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of translationIMP:UniProtKB
Positive regulation of translationIMP:UniProtKB
Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB