OTUD6B
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA5 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM
Full Name
OTUD6B
Function
Isoform 1
Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334).
May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334).
May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334).
May also play a role in proteasome assembly and function (PubMed:28343629).
Isoform 2
Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.
Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334).
May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334).
May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334).
May also play a role in proteasome assembly and function (PubMed:28343629).
Isoform 2
Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of translationIMP:UniProtKB
Positive regulation of translationIMP:UniProtKB
Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of translationIMP:UniProtKB
Positive regulation of translationIMP:UniProtKB
Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
View more
Anti-OTUD6B antibodies
+ Filters
Loading...
CompareTarget: OTUD6B
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3H4
Application*: E, WB
Target: OTUD6B
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 11F7
Application*: E, M
Target: OTUD6B
Expressed Host: E. coli
Sequence: Amino Acid: Full Length
Tag: His Tag
More Infomation
Hot products 
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry