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Mouse Anti-OTUD6B Recombinant Antibody (11F7) (CBMAB-0788-CN)

This product is a mouse antibody that recognizes OTUD6B of human. The antibody 11F7 can be used for immunoassay techniques such as: ELISA, MA.
See all OTUD6B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11F7
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant full length protein of OTUD6B
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
OTUD6B
Introduction
OTUD6B is a functional deubiquitinating enzyme, a class of protease that specifically cleaves ubiquitin linkages, negating the action of ubiquitin ligases. This gene encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Deubiquitinating enzymes are primarily involved in removing ubiquitin from proteins targeted for degradation. This protein may function as a negative regulator of the cell cycle in B cells.
Entrez Gene ID
51633
UniProt ID
Q8N6M0
Alternative Names
DUBA5; CGI-77; DUBA-5; IDDFSDA
Function
Isoform 1
Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334).
May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334).
May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334).
May also play a role in proteasome assembly and function (PubMed:28343629).
Isoform 2
Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of translationIMP:UniProtKB
Positive regulation of translationIMP:UniProtKB
Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB

Li, L., Zhu, R., Zhou, H., Cui, C. P., Yu, X., Liu, Y., ... & Liu, Z. (2023). All‐Trans Retinoic Acid Promotes a Tumor Suppressive OTUD6B‐β‐TrCP‐SNAIL Axis in Esophageal Squamous Cell Carcinoma and Enhances Immunotherapy. Advanced Science, 10(16), 2207458.

Wang, Z., Zhang, L., Li, L., & Zhou, M. (2022). Loss of OTUD6B stimulates angiogenesis and promotes diabetic atherosclerosis. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 3027-3038.

Cingöz, S., Soydemir, D., Öner, T. Ö., Karaca, E., Özden, B., Kurul, S. H., ... & University of Washington Center for Mendelian Genomics. (2022). Novel biallelic variants affecting the OTU domain of the gene OTUD6B associate with severe intellectual disability syndrome and molecular dynamics simulations. European journal of medical genetics, 65(6), 104497.

Zhao, G., Song, D., Wu, J., Yang, S., & Zhang, B. (2022). Identification of OTUD6B as a new biomarker for prognosis and immunotherapy by pan-cancer analysis. Frontiers in immunology, 13, 955091.

Guo, K., Wei, Y., Wang, Z., Zhang, X., Zhang, X., Liu, X., ... & Cui, C. P. (2022). Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma. Cell Death & Disease, 13(2), 97.

Abdel-Salam, G. M., Abdel-Hamid, M. S., Sayed, I. S., Zechner, U., & Bolz, H. J. (2022). OTUD6B-associated intellectual disability: Novel variants and genetic exclusion of retinal degeneration as part of a refined phenotype. Journal of Human Genetics, 67(1), 55-64.

Zhou, Z., Cai, X., Zhu, J., Li, Z., Yu, G., Liu, X., ... & Xiao, W. (2021). Zebrafish otud6b negatively regulates antiviral responses by suppressing K63-linked ubiquitination of irf3 and irf7. The Journal of Immunology, 207(1), 244-256.

Liu, X., Zhang, X., Peng, Z., Li, C., Wang, Z., Wang, C., ... & Zhang, L. (2020). Deubiquitylase OTUD6B governs pVHL stability in an enzyme‐independent manner and suppresses hepatocellular carcinoma metastasis. Advanced Science, 7(8), 1902040.

Kong, S., Xue, H., Li, Y., Li, P., Ma, F., Liu, M., & Li, W. (2020). The long noncoding RNA OTUD6B-AS1 enhances cell proliferation and the invasion of hepatocellular carcinoma cells through modulating GSKIP/Wnt/β-catenin signalling via the sequestration of miR-664b-3p. Experimental Cell Research, 395(1), 112180.

Wang, G., Zhang, Z. J., Jian, W. G., Liu, P. H., Xue, W., Wang, T. D., ... & Zhang, C. (2019). Novel long noncoding RNA OTUD6B-AS1 indicates poor prognosis and inhibits clear cell renal cell carcinoma proliferation via the Wnt/β-catenin signaling pathway. Molecular cancer, 18, 1-15.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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