Human Recombinant OTUD6B protein, His Tag (V2LY-0526-LY5896)

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Basic Information

Expressed Host
E. coli
Protein Species
Human
Tag
His Tag
Protein Construction
This product is Human Recombinant OTUD6B protein, His Tag consist of Amino Acid: Full Length and predicts a molecular mass of 37 kDa.
Molecule Mass
37 kDa
Sequence
Amino Acid: Full Length
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Buffer
PBS
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
OTUD6B
Function
Isoform 1
Deubiquitinating enzyme that may play a role in the ubiquitin-dependent regulation of protein synthesis, downstream of mTORC1 (PubMed:21267069, PubMed:27864334).
May associate with the protein synthesis initiation complex and modify its ubiquitination to repress translation (PubMed:27864334).
May also repress DNA synthesis and modify different cellular targets thereby regulating cell growth and proliferation (PubMed:27864334).
May also play a role in proteasome assembly and function (PubMed:28343629).
Isoform 2
Stimulates protein synthesis. Influences the expression of CCND1/cyclin D1 by promoting its translation and regulates MYC/c-Myc protein stability.
Biological Process
Cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of translationIMP:UniProtKB
Positive regulation of translationIMP:UniProtKB
Proteasome assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Protein deubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB

Li, L., Zhu, R., Zhou, H., Cui, C. P., Yu, X., Liu, Y., ... & Liu, Z. (2023). All‐Trans Retinoic Acid Promotes a Tumor Suppressive OTUD6B‐β‐TrCP‐SNAIL Axis in Esophageal Squamous Cell Carcinoma and Enhances Immunotherapy. Advanced Science, 10(16), 2207458.

Wang, Z., Zhang, L., Li, L., & Zhou, M. (2022). Loss of OTUD6B stimulates angiogenesis and promotes diabetic atherosclerosis. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, 3027-3038.

Cingöz, S., Soydemir, D., Öner, T. Ö., Karaca, E., Özden, B., Kurul, S. H., ... & University of Washington Center for Mendelian Genomics. (2022). Novel biallelic variants affecting the OTU domain of the gene OTUD6B associate with severe intellectual disability syndrome and molecular dynamics simulations. European journal of medical genetics, 65(6), 104497.

Zhao, G., Song, D., Wu, J., Yang, S., & Zhang, B. (2022). Identification of OTUD6B as a new biomarker for prognosis and immunotherapy by pan-cancer analysis. Frontiers in immunology, 13, 955091.

Guo, K., Wei, Y., Wang, Z., Zhang, X., Zhang, X., Liu, X., ... & Cui, C. P. (2022). Deubiquitylase OTUD6B stabilizes the mutated pVHL and suppresses cell migration in clear cell renal cell carcinoma. Cell Death & Disease, 13(2), 97.

Abdel-Salam, G. M., Abdel-Hamid, M. S., Sayed, I. S., Zechner, U., & Bolz, H. J. (2022). OTUD6B-associated intellectual disability: Novel variants and genetic exclusion of retinal degeneration as part of a refined phenotype. Journal of Human Genetics, 67(1), 55-64.

Zhou, Z., Cai, X., Zhu, J., Li, Z., Yu, G., Liu, X., ... & Xiao, W. (2021). Zebrafish otud6b negatively regulates antiviral responses by suppressing K63-linked ubiquitination of irf3 and irf7. The Journal of Immunology, 207(1), 244-256.

Liu, X., Zhang, X., Peng, Z., Li, C., Wang, Z., Wang, C., ... & Zhang, L. (2020). Deubiquitylase OTUD6B governs pVHL stability in an enzyme‐independent manner and suppresses hepatocellular carcinoma metastasis. Advanced Science, 7(8), 1902040.

Kong, S., Xue, H., Li, Y., Li, P., Ma, F., Liu, M., & Li, W. (2020). The long noncoding RNA OTUD6B-AS1 enhances cell proliferation and the invasion of hepatocellular carcinoma cells through modulating GSKIP/Wnt/β-catenin signalling via the sequestration of miR-664b-3p. Experimental Cell Research, 395(1), 112180.

Wang, G., Zhang, Z. J., Jian, W. G., Liu, P. H., Xue, W., Wang, T. D., ... & Zhang, C. (2019). Novel long noncoding RNA OTUD6B-AS1 indicates poor prognosis and inhibits clear cell renal cell carcinoma proliferation via the Wnt/β-catenin signaling pathway. Molecular cancer, 18, 1-15.

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For research use only. Not intended for any clinical use.

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