OXTR

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.

Full Name

Oxytocin Receptor

Function

Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

Biological Process

Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Digestive tract developmentIEA:Ensembl
Eating behaviorIEA:Ensembl
ERK1 and ERK2 cascadeIEA:Ensembl
Estrous cycleIEA:Ensembl
Female pregnancyManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Heart developmentIEA:Ensembl
LactationManual Assertion Based On ExperimentTAS:ProtInc
Maternal behaviorIEA:Ensembl
Maternal process involved in parturitionManual Assertion Based On ExperimentIBA:GO_Central
MemoryIEA:Ensembl
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of gastric acid secretionIEA:Ensembl
Positive regulation of blood pressureIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Positive regulation of norepinephrine secretionIEA:Ensembl
Positive regulation of penile erectionIEA:Ensembl
Positive regulation of synapse assemblyIEA:Ensembl
Positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Positive regulation of synaptic transmission, glutamatergicIEA:Ensembl
Positive regulation of uterine smooth muscle contractionIEA:Ensembl
Positive regulation of vasoconstrictionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of systemic arterial blood pressure by vasopressinManual Assertion Based On ExperimentIBA:GO_Central
Response to amphetamineIEA:Ensembl
Response to anoxiaIEA:Ensembl
Response to cocaineIEA:Ensembl
Response to cytokineIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to peptide hormoneIEA:Ensembl
Response to progesteroneIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
SleepIEA:Ensembl
Social behaviorIEA:Ensembl
Sperm ejaculationIEA:Ensembl
Suckling behaviorIEA:Ensembl
Telencephalon developmentIEA:Ensembl

Topology

Extracellular: 1-38
Helical: 39-63
Cytoplasmic: 64-74
Helical: 75-97
Extracellular: 98-113
Helical: 114-135
Cytoplasmic: 136-154
Helical: 155-175
Extracellular: 176-202
Helical: 203-225
Cytoplasmic: 226-275
Helical: 276-294
Extracellular: 295-309
Helical: 310-332
Cytoplasmic: 333-389