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Rabbit Anti-OXTR Recombinant Antibody (BA0116) (CBMAB-0568CQ)

This product is a rabbit antibody that recognizes OXTR. The antibody BA0116 can be used for immunoassay techniques such as: WB.
See all OXTR antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0116
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Human Oxytocin Receptor aa 50-150
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Oxytocin Receptor
Introduction
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland.
Entrez Gene ID
Human5021
Mouse18430
Rat25342
UniProt ID
HumanP30559
MouseP97926
RatP70536
Alternative Names
OT-R
Function
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Digestive tract developmentIEA:Ensembl
Eating behaviorIEA:Ensembl
ERK1 and ERK2 cascadeIEA:Ensembl
Estrous cycleIEA:Ensembl
Female pregnancyManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Heart developmentIEA:Ensembl
LactationManual Assertion Based On ExperimentTAS:ProtInc
Maternal behaviorIEA:Ensembl
Maternal process involved in parturitionManual Assertion Based On ExperimentIBA:GO_Central
MemoryIEA:Ensembl
Muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of gastric acid secretionIEA:Ensembl
Positive regulation of blood pressureIEA:Ensembl
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of cytosolic calcium ion concentrationIEA:Ensembl
Positive regulation of norepinephrine secretionIEA:Ensembl
Positive regulation of penile erectionIEA:Ensembl
Positive regulation of synapse assemblyIEA:Ensembl
Positive regulation of synaptic transmission, GABAergicIEA:Ensembl
Positive regulation of synaptic transmission, glutamatergicIEA:Ensembl
Positive regulation of uterine smooth muscle contractionIEA:Ensembl
Positive regulation of vasoconstrictionManual Assertion Based On ExperimentIBA:GO_Central
Regulation of systemic arterial blood pressure by vasopressinManual Assertion Based On ExperimentIBA:GO_Central
Response to amphetamineIEA:Ensembl
Response to anoxiaIEA:Ensembl
Response to cocaineIEA:Ensembl
Response to cytokineIEA:Ensembl
Response to estradiolIEA:Ensembl
Response to peptide hormoneIEA:Ensembl
Response to progesteroneIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
SleepIEA:Ensembl
Social behaviorIEA:Ensembl
Sperm ejaculationIEA:Ensembl
Suckling behaviorIEA:Ensembl
Telencephalon developmentIEA:Ensembl
Topology
Extracellular: 1-38
Helical: 39-63
Cytoplasmic: 64-74
Helical: 75-97
Extracellular: 98-113
Helical: 114-135
Cytoplasmic: 136-154
Helical: 155-175
Extracellular: 176-202
Helical: 203-225
Cytoplasmic: 226-275
Helical: 276-294
Extracellular: 295-309
Helical: 310-332
Cytoplasmic: 333-389

Pierzynowska, K., Gaffke, L., Żabińska, M., Cyske, Z., Rintz, E., Wiśniewska, K., ... & Węgrzyn, G. (2023). Roles of the oxytocin receptor (OXTR) in human diseases. International journal of molecular sciences, 24(4), 3887.

Kohlhoff, J., Cibralic, S., Hawes, D. J., & Eapen, V. (2022). Oxytocin receptor gene (OXTR) polymorphisms and social, emotional and behavioral functioning in children and adolescents: A systematic narrative review. Neuroscience & Biobehavioral Reviews, 135, 104573.

Rokicki, J., Kaufmann, T., De Lange, A. M. G., van der Meer, D., Bahrami, S., Sartorius, A. M., ... & Quintana, D. S. (2022). Oxytocin receptor expression patterns in the human brain across development. Neuropsychopharmacology, 47(8), 1550-1560.

Moerkerke, M., Bonte, M. L., Daniels, N., Chubar, V., Alaerts, K., Steyaert, J., & Boets, B. (2021). Oxytocin receptor gene (OXTR) DNA methylation is associated with autism and related social traits–A systematic review. Research in Autism Spectrum Disorders, 85, 101785.

Danoff, J. S., Wroblewski, K. L., Graves, A. J., Quinn, G. C., Perkeybile, A. M., Kenkel, W. M., ... & Connelly, J. J. (2021). Genetic, epigenetic, and environmental factors controlling oxytocin receptor gene expression. Clinical epigenetics, 13, 1-16.

Zheng, S., Masuda, T., Matsunaga, M., Noguchi, Y., Ohtsubo, Y., Yamasue, H., & Ishii, K. (2020). Oxytocin receptor gene (OXTR) and childhood adversity influence trust. Psychoneuroendocrinology, 121, 104840.

Tops, S., Habel, U., & Radke, S. (2019). Genetic and epigenetic regulatory mechanisms of the oxytocin receptor gene (OXTR) and the (clinical) implications for social behavior. Hormones and behavior, 108, 84-93.

Kraaijenvanger, E. J., He, Y., Spencer, H., Smith, A. K., Bos, P. A., & Boks, M. P. (2019). Epigenetic variability in the human oxytocin receptor (OXTR) gene: A possible pathway from early life experiences to psychopathologies. Neuroscience & Biobehavioral Reviews, 96, 127-142.

Ebner, N. C., Lin, T., Muradoglu, M., Weir, D. H., Plasencia, G. M., Lillard, T. S., ... & Connelly, J. J. (2019). Associations between oxytocin receptor gene (OXTR) methylation, plasma oxytocin, and attachment across adulthood. International Journal of Psychophysiology, 136, 22-32.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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