Sign in or Register   Sign in or Register
  |  

PACSIN2

PACSIN2 is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization.
Full Name
protein kinase C and casein kinase substrate in neurons 2
Function
Regulates the morphogenesis and endocytosis of caveolae (By similarity).
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700).
Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077).
Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866).
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentTAS:ProtInc
Caveola assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Caveolin-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Cell projection morphogenesisISS:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionIEA:Ensembl
Negative regulation of endocytosisIEA:Ensembl
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to endosomeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Cytoplasmic vesicle membrane
Early endosome
Recycling endosome membrane
Cell projection, ruffle membrane
Cell membrane
Cell projection
Membrane, caveola
Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
PTM
Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (By similarity).

Anti-PACSIN2 antibodies

Loading...
Target: PACSIN2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: 1735CT116.76.60
Application*: E, WB
Target: PACSIN2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3D6
Application*: E, P, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
Go to
Compare