PACSIN2

PACSIN2 is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization.

Full Name

protein kinase C and casein kinase substrate in neurons 2

Function

Regulates the morphogenesis and endocytosis of caveolae (By similarity).
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700).
Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077).
Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866).

Biological Process

Actin cytoskeleton organizationManual Assertion Based On ExperimentTAS:ProtInc
Caveola assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Caveolin-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Cell projection morphogenesisISS:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionIEA:Ensembl
Negative regulation of endocytosisIEA:Ensembl
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to endosomeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Cytoplasm, cytoskeleton
Cytoplasmic vesicle membrane
Early endosome
Recycling endosome membrane
Cell projection, ruffle membrane
Cell membrane
Cell projection
Membrane, caveola
Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.

PTM

Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (By similarity).