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Mouse Anti-PACSIN2 Recombinant Antibody (3D6) (CBMAB-P0633-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase C And Casein Kinase Substrate In Neurons 2. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all PACSIN2 antibodies
Published Data

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D6
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein kinase C and casein kinase substrate in neurons 2
Introduction
PACSIN2 is a member of the protein kinase C and casein kinase substrate in neurons family. The encoded protein is involved in linking the actin cytoskeleton with vesicle formation by regulating tubulin polymerization.
Entrez Gene ID
UniProt ID
Alternative Names
Protein Kinase C And Casein Kinase Substrate In Neurons 2; Syndapin-II; Syndapin-2; Protein Kinase C And Casein Kinase Substrate In Neurons Protein 2; Cytoplasmic Phosphoprotein PACSIN2; Syndapin II; Syndapin2; SDPII;
Function
Regulates the morphogenesis and endocytosis of caveolae (By similarity).
Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus.
(Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700).
Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077).
Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866).
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentTAS:ProtInc
Caveola assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Caveolin-mediated endocytosisManual Assertion Based On ExperimentIMP:UniProtKB
Cell projection morphogenesisISS:UniProtKB
Cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Modulation of chemical synaptic transmissionIEA:Ensembl
Negative regulation of endocytosisIEA:Ensembl
Plasma membrane tubulationManual Assertion Based On ExperimentIDA:UniProtKB
Protein localization to endosomeManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of endocytosisManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
Cytoplasm, cytoskeleton
Cytoplasmic vesicle membrane
Early endosome
Recycling endosome membrane
Cell projection, ruffle membrane
Cell membrane
Cell projection
Membrane, caveola
Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
PTM
Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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