PADI2

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq]

peptidyl arginine deiminase, type II

Catalyzes the deimination of arginine residues of proteins.

Cellular response to leukemia inhibitory factorIEA:Ensembl
Epigenetic maintenance of chromatin in transcription-competent conformationManual Assertion Based On ExperimentIMP:UniProtKB
Histone citrullinationManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-R26 citrullinationManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of lymphocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Protein citrullinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of chromatin disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cytoplasm