Mouse Anti-PADI2 Recombinant Antibody (4D4) (CBMAB-P0640-YC)

Name: Mouse Anti-PADI2 Recombinant Antibody (4D4)
SKU: CBMAB-P0640-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4D4

Application

WB, IP, ELISA

Specificity

Human, Mouse

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

peptidyl arginine deiminase, type II

Introduction

PADI2 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes.

Entrez Gene ID

Human	11240
Mouse	18600

UniProt ID

Human	Q9Y2J8
Mouse	Q08642

Alternative Names

Peptidyl Arginine Deiminase 2; Peptidyl Arginine Deiminase, Type II; Protein-Arginine Deiminase Type II; EC 3.5.3.15; PAD-H19; PAD2;

Function

Catalyzes the deimination of arginine residues of proteins.

Biological Process

Cellular response to leukemia inhibitory factorIEA:Ensembl
Epigenetic maintenance of chromatin in transcription-competent conformationManual Assertion Based On ExperimentIMP:UniProtKB
Histone citrullinationManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-R26 citrullinationManual Assertion Based On ExperimentIDA:UniProtKB
Intracellular estrogen receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of lymphocyte chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Protein citrullinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of chromatin disassemblyManual Assertion Based On ExperimentIDA:UniProtKB
Substantia nigra developmentManual Assertion Based On ExperimentHEP:UniProtKB

Cellular Location

Cytoplasm

Nava-Quiroz, K. J., Rojas-Serrano, J., Pérez-Rubio, G., Buendia-Roldan, I., Mejía, M., Fernández-López, J. C., ... & Falfán-Valencia, R. (2023). Molecular factors in PAD2 (PADI2) and PAD4 (PADI4) are associated with interstitial lung disease susceptibility in rheumatoid arthritis patients. Cells, 12(18), 2235.

Ballasy, N. N., Bering, E. A., Kokorudz, C., Radford, B. N., Zhao, X., Dean, W., & Hemberger, M. (2022). Padi2/3 deficiency alters the epigenomic landscape and causes premature differentiation of mouse trophoblast stem cells. Cells, 11(16), 2466.

Kim, H. J., Kim, W. J., Shin, H. R., Yoon, H. I., Moon, J. I., Lee, E., ... & Ryoo, H. M. (2022). ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation. Cellular and Molecular Life Sciences, 79(3), 155.

Ma, X., Wang, G., Fan, H., Li, Z., Chen, W., Xiao, J., ... & Yang, L. (2022). Long noncoding RNA FAM225A promotes the malignant progression of gastric cancer through the miR-326/PADI2 axis. Cell Death Discovery, 8(1), 20.

Sams, K. L., Mukai, C., Marks, B. A., Mittal, C., Demeter, E. A., Nelissen, S., ... & Coonrod, S. A. (2022). Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice. Reproductive Biology and Endocrinology, 20(1), 150.

Xue, T., Liu, X., Zhang, M., E, Q., Liu, S., Zou, M., ... & Zhang, X. (2021). PADI2‐catalyzed MEK1 citrullination activates ERK1/2 and promotes IGF2BP1‐mediated SOX2 mRNA stability in endometrial cancer. Advanced Science, 8(6), 2002831.

Guzmán-Guzmán, I. P., Ramírez-Vélez, C. I., Falfán-Valencia, R., Navarro-Zarza, J. E., Gutiérrez-Pérez, I. A., Zaragoza-García, O., & Parra-Rojas, I. (2021). PADI2 polymorphisms are significantly associated with rheumatoid arthritis, autoantibodies serologic status and joint damage in women from southern Mexico. Frontiers in Immunology, 12, 718246.

Beato, M., & Sharma, P. (2020). Peptidyl arginine deiminase 2 (PADI2)-mediated arginine citrullination modulates transcription in cancer. International Journal of Molecular Sciences, 21(4), 1351.

Liu, L., Zhang, Z., Zhang, G., Wang, T., Ma, Y., & Guo, W. (2020). Down-regulation of PADI2 prevents proliferation and epithelial-mesenchymal transition in ovarian cancer through inhibiting JAK2/STAT3 pathway in vitro and in vivo, alone or in combination with Olaparib. Journal of translational medicine, 18, 1-19.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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