PANK4

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]
Full Name
Pantothenate Kinase 4
Function
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068).
Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068).
Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068).
May play a role in the physiological regulation of CoA intracellular levels (Probable).
Biological Process
Coenzyme A biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
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Anti-PANK4 antibodies

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Rabbit Anti-PANK4 Recombinant Antibody (D8N2C) (CBMAB-CP1861-LY)

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Target: PANK4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D8N2C
Application*: WB, IP
Datasheet SDS

Rabbit Anti-PANK4 Recombinant Antibody (D6J4R) (CBMAB-CP1860-LY)

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Target: PANK4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D6J4R
Application*: WB
Datasheet SDS

Mouse Anti-PANK4 Recombinant Antibody (3C1) (CBMAB-A6318-LY)

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Target: PANK4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C1
Application*: SE, E
Datasheet SDS

Mouse Anti-PANK4 Recombinant Antibody (2A11) (CBMAB-A6317-LY)

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Target: PANK4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A11
Application*: IH, E
Datasheet SDS

Mouse Anti-PANK4 Recombinant Antibody (CBYC-P157) (CBMAB-P0733-YC)

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Target: PANK4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYC-P157
Application*: E
Datasheet SDS

Mouse Anti-PANK4 Recombinant Antibody (4F10) (CBMAB-P0732-YC)

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Target: PANK4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4F10
Application*: E, P
Datasheet SDS

PANK4 Matched Antibody Pair (840) (APMAB-840LY)

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Target: PANK4
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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