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PANK4

This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]

Full Name

Pantothenate Kinase 4

Function

Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068).
Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068).
Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068).
May play a role in the physiological regulation of CoA intracellular levels (Probable).

Biological Process

Coenzyme A biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

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Anti-PANK4 antibodies

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Rabbit Anti-PANK4 Recombinant Antibody (D8N2C) (CBMAB-CP1861-LY)

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Target: PANK4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Hamster, Monkey

Clone: D8N2C

Application*: WB, IP

Rabbit Anti-PANK4 Recombinant Antibody (D6J4R) (CBMAB-CP1860-LY)

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Target: PANK4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Hamster, Monkey

Clone: D6J4R

Application*: WB

Mouse Anti-PANK4 Recombinant Antibody (3C1) (CBMAB-A6318-LY)

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Target: PANK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3C1

Application*: SE, E

Mouse Anti-PANK4 Recombinant Antibody (2A11) (CBMAB-A6317-LY)

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Target: PANK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2A11

Application*: IH, E

Mouse Anti-PANK4 Recombinant Antibody (CBYC-P157) (CBMAB-P0733-YC)

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Target: PANK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBYC-P157

Application*: E

Mouse Anti-PANK4 Recombinant Antibody (4F10) (CBMAB-P0732-YC)

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Target: PANK4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4F10

Application*: E, P

PANK4 Matched Antibody Pair (840) (APMAB-840LY)

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Target: PANK4

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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