Mouse Anti-PANK4 Recombinant Antibody (CBYC-P157) (CBMAB-P0733-YC)

Name: Mouse Anti-PANK4 Recombinant Antibody (CBYC-P157)
SKU: CBMAB-P0733-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYC-P157

Application

ELISA

Immunogen

PANK4 (NP_060686.1, 673-773 aa) partial recombinant protein with GST tag.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.2

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Pantothenate Kinase 4

Introduction

PANK4 is a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.

Entrez Gene ID

55229

UniProt ID

Q9NVE7

Alternative Names

Pantothenate Kinase 4; Pantothenic Acid Kinase 4; EC 2.7.1.33; HPanK4;

Function

Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068).
Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068).
Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068).
May play a role in the physiological regulation of CoA intracellular levels (Probable).

Biological Process

Coenzyme A biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm

Vella, V., Ditsiou, A., Chalari, A., Eravci, M., Wooller, S. K., Gagliano, T., ... & Giamas, G. (2024). Kinome‐Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma. Advanced Science, 2306027.

Vella, V., Ditsiou, A., Chalari, A., Eravci, M., Wooler, S. K., Gagliano, T., ... & Zhang, Y. (2023). Kinome-wide synthetic lethal screen identifies PANK4 as modulator of resistance in glioblastoma.

Guan, J., Zhang, L., & Zhou, F. (2022). PI3K-PANK4: a new target for de novo synthesis of coenzyme A. Molecular Biomedicine, 3(1), 33.

Sun, M., Chen, C., Hou, S., Li, X., Wang, H., Zhou, J., ... & Ye, J. (2019). A novel mutation of PANK4 causes autosomal dominant congenital posterior cataract. Human mutation, 40(4), 380-391.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Antibody Pairs

PANK4 Matched Antibody Pair (840) (CAT#: APMAB-840LY)

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Rabbit Anti-PANK4 Recombinant Antibody (D8N2C) (CAT#: CBMAB-CP1861-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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