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Mouse Anti-PANK4 Recombinant Antibody (CBYC-P157) (CBMAB-P0733-YC)

Provided herein is a Mouse monoclonal antibody against Human Pantothenate Kinase 4. The antibody can be used for immunoassay techniques, such as ELISA.
See all PANK4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P157
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
PANK4 (NP_060686.1, 673-773 aa) partial recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pantothenate Kinase 4
Introduction
PANK4 is a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues.
Entrez Gene ID
55229
UniProt ID
Q9NVE7
Alternative Names
Pantothenate Kinase 4; Pantothenic Acid Kinase 4; EC 2.7.1.33; HPanK4;
Function
Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway (PubMed:27322068).
Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms (PubMed:27322068).
Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein (PubMed:27322068).
May play a role in the physiological regulation of CoA intracellular levels (Probable).
Biological Process
Coenzyme A biosynthetic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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