PDCL3

This gene encodes a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins. [provided by RefSeq]

Full Name

phosducin-like 3

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764).
Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077).
Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity).
Modulates the activation of caspases during apoptosis (PubMed:15371430).

Biological Process

Actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
AngiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Apoptotic processIEA:UniProtKB-KW
Chaperone-mediated protein foldingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of chaperone-mediated protein foldingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:MGI
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:MGI
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:MGI
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Endoplasmic reticulum

PTM

N-terminal methionine acetylation destabilizes the protein.