Mouse Anti-PDCL3 Recombinant Antibody (16C75) (CBMAB-P1177-YC)

Name: Mouse Anti-PDCL3 Recombinant Antibody (16C75)
SKU: CBMAB-P1177-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

16C75

Application

ELISA, WB

Immunogen

Recombinant protein corresponding to aa1-239 from human PDCL3 expressed in E. coli

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid in PBS, pH 7.4, 0.02% sodium azide, 10% glycerol

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

phosducin-like 3

Introduction

PDCL3 is a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins.

Entrez Gene ID

79031

UniProt ID

Q9H2J4

Alternative Names

Phosducin Like 3; Viral IAP-Associated Factor 1; PHLP2A; HTPHLP; VIAF-1; PhPL3;

Function

Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764).
Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077).
Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity).
Modulates the activation of caspases during apoptosis (PubMed:15371430).

Biological Process

Actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
AngiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Apoptotic processIEA:UniProtKB-KW
Chaperone-mediated protein foldingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of chaperone-mediated protein foldingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:MGI
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:MGI
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:MGI
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:MGI

Cellular Location

Cytoplasm
Cytoplasm, perinuclear region
Endoplasmic reticulum

PTM

N-terminal methionine acetylation destabilizes the protein.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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