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Mouse Anti-PDCL3 Recombinant Antibody (F-4) (CBMAB-P1180-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosducin Like 3. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PDCL3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
F-4
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phosducin-like 3
Introduction
PDCL3 is a member of the phosducin-like protein family and is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin. Members of the phosducin-like protein family have been shown to bind to the beta-gamma subunits of G proteins.
Entrez Gene ID
79031
UniProt ID
Q9H2J4
Alternative Names
Phosducin Like 3; Viral IAP-Associated Factor 1; PHLP2A; HTPHLP; VIAF-1; PhPL3;
Function
Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764).
Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077).
Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity).
Modulates the activation of caspases during apoptosis (PubMed:15371430).
Biological Process
Actin cytoskeleton organizationManual Assertion Based On ExperimentIMP:UniProtKB
AngiogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Apoptotic processIEA:UniProtKB-KW
Chaperone-mediated protein foldingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of chaperone-mediated protein foldingManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:MGI
Positive regulation of angiogenesisManual Assertion Based On ExperimentIMP:MGI
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIMP:MGI
Positive regulation of gene expressionManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of peptidyl-tyrosine phosphorylationManual Assertion Based On ExperimentIMP:MGI
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Endoplasmic reticulum
PTM
N-terminal methionine acetylation destabilizes the protein.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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