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PDS5A

PDS5A binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis.

Full Name

PDS5 Cohesin Associated Factor A

Function

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Biological Process

Cell divisionIEA:UniProtKB-KW
DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Mitotic sister chromatid cohesionManual Assertion Based On ExperimentIPI:UniProtKB
Negative regulation of DNA replicationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.

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Anti-PDS5A antibodies

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Mouse Anti-PDS5A Recombinant Antibody (CBXS-2002) (CBMAB-S4769-CQ)

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Target: PDS5A

Host: Mouse

Specificity: Human

Clone: CBXS-2002

Application*: WB, IP, IF, E

Recombinant Mouse Anti-PDS5A Recombinant Antibody (AF5-21-7) (CBMAB-XB0918-YC)

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Target: PDS5A

Host: Mouse

Specificity: Human, Mouse

Clone: AF5-21-7

Application*: IH, IF, IP, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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