PDS5A

PDS5A binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis.

Full Name

PDS5 Cohesin Associated Factor A

Function

Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.

Biological Process

Cell divisionIEA:UniProtKB-KW
DNA repairManual Assertion Based On ExperimentIBA:GO_Central
Mitotic sister chromatid cohesionManual Assertion Based On ExperimentIPI:UniProtKB
Negative regulation of DNA replicationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Nucleus
Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase.

Anti-PDS5A antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Recombinant Mouse Anti-PDS5A Recombinant Antibody (AF5-21-7) (CBMAB-XB0918-YC)

Datasheet

SDS

Target: PDS5A

Host: Mouse

Specificity: Human, Mouse

Clone: AF5-21-7

Application*: IH, IF, IP, WB

Mouse Anti-PDS5A Recombinant Antibody (CBXS-2002) (CBMAB-S4769-CQ)

Datasheet

SDS

Target: PDS5A

Host: Mouse

Specificity: Human

Clone: CBXS-2002

Application*: WB, IP, IF, E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)