PKMYT1

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
Full Name
protein kinase, membrane associated tyrosine/threonine 1
Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Biological Process
G2/M transition of mitotic cell cycleTAS:Reactome
Meiotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentTAS:ProtInc
Regulation of mitotic nuclear divisionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
PTM
Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
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Anti-PKMYT1 antibodies

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Mouse Anti-PKMYT1 Recombinant Antibody (5E1) (CBMAB-P1948-YC)

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Target: PKMYT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5E1
Application*: F, IF, IH, WB
Datasheet SDS

Mouse Anti-PKMYT1 Recombinant Antibody (50) (CBMAB-P1947-YC)

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Target: PKMYT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Monkey
Clone: 50
Application*: WB, F, IH, IC, IF, P
Datasheet SDS

Mouse Anti-PKMYT1 Recombinant Antibody (2B4) (CBMAB-P1946-YC)

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Target: PKMYT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2B4
Application*: IH, WB
Datasheet SDS

Mouse Anti-PKMYT1 Recombinant Antibody (2A3) (CBMAB-P1945-YC)

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Target: PKMYT1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2A3
Application*: E, PLA, WB
Datasheet SDS

Mouse Anti-PKMYT1 Recombinant Antibody (1C3) (CBMAB-P1944-YC)

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Target: PKMYT1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1C3
Application*: IC, IF, WB
Datasheet SDS

Human Recombinant PKMYT1, Active protein, His Tag (V2LY-0526-LY6213)

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Target: PKMYT1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: His Tag
Datasheet SDS

Human Recombinant PKMYT1, Active protein, GST Tag (V2LY-0526-LY6212)

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Target: PKMYT1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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