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Mouse Anti-PKMYT1 Recombinant Antibody (50) (CBMAB-P1947-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein Kinase, Membrane Associated Tyrosine/Threonine 1. The antibody can be used for immunoassay techniques, such as WB, FC, IHC, ICC, IF, IHC-P.
See all PKMYT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Monkey
Clone
50
Antibody Isotype
IgG2a
Application
WB, FC, IHC, ICC, IF, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human PKMYT1 (NP_004194) produced in HEK293T cell
Specificity
Human, Monkey
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein kinase, membrane associated tyrosine/threonine 1
Introduction
PKMYT1 is a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1.
Entrez Gene ID
Human9088
Monkey699350
UniProt ID
HumanQ99640
MonkeyF6Z3J0
Alternative Names
PPP1R126; MYT1
Function
Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development.
Biological Process
G2/M transition of mitotic cell cycleTAS:Reactome
Meiotic cell cycleManual Assertion Based On ExperimentIBA:GO_Central
Mitotic cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cyclin-dependent protein serine/threonine kinase activityManual Assertion Based On ExperimentTAS:ProtInc
Regulation of mitotic nuclear divisionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Endoplasmic reticulum membrane
Golgi apparatus membrane
PTM
Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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