PMAIP1

PMAIP1 (Phorbol-12-Myristate-13-Acetate-Induced Protein 1) is a protein coding gene. Diseases associated with PMAIP1 include Adult T-Cell Leukemia and Ischemic Neuropathy. Among its related pathways are Gene Expression and Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins.

Full Name

Phorbol-12-Myristate-13-Acetate-Induced Protein 1

Function

Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity).
Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

Biological Process

Activation of cysteine-type endopeptidase activity involved in apoptotic processIEA:InterPro
Apoptotic processManual Assertion Based On ExperimentIMP:MGI
Cellular response to DNA damage stimulusIEA:InterPro
Cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to hypoxiaManual Assertion Based On ExperimentIEP:UniProtKB
Defense response to virusManual Assertion Based On ExperimentIDA:BHF-UCL
Intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of mitochondrial membrane potentialBy SimilarityISS:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of glucose metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:UniProtKB
Proteasomal protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitochondrial membrane permeabilityManual Assertion Based On ExperimentIDA:UniProtKB
Release of cytochrome c from mitochondriaIEA:InterPro
Response to dsRNAManual Assertion Based On ExperimentIDA:HGNC-UCL
T cell homeostasisISS:UniProtKB

Cellular Location

Mitochondrion