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Rat Anti-PMAIP1 Recombinant Antibody (69N15C9) (CBMAB-N0575-WJ)

This product is a Rat antibody that recognizes PMAIP1. The antibody 69N15C9 can be used for immunoassay techniques such as: WB.
See all PMAIP1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
69N15C9
Antibody Isotype
IgG2b, κ
Application
WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phorbol-12-Myristate-13-Acetate-Induced Protein 1
Introduction
PMAIP1 is a protein coding gene.
Entrez Gene ID
58801
UniProt ID
Q9JM54
Alternative Names
APR; NOXA
Function
Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity).
Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
Biological Process
Activation of cysteine-type endopeptidase activity involved in apoptotic processIEA:InterPro
Apoptotic processManual Assertion Based On ExperimentIMP:MGI
Cellular response to DNA damage stimulusIEA:InterPro
Cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to hypoxiaManual Assertion Based On ExperimentIEP:UniProtKB
Defense response to virusManual Assertion Based On ExperimentIDA:BHF-UCL
Intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of mitochondrial membrane potentialBy SimilarityISS:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of DNA damage response, signal transduction by p53 class mediatorManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptorsManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of glucose metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of intrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:UniProtKB
Proteasomal protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Reactive oxygen species metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitochondrial membrane permeabilityManual Assertion Based On ExperimentIDA:UniProtKB
Release of cytochrome c from mitochondriaIEA:InterPro
Response to dsRNAManual Assertion Based On ExperimentIDA:HGNC-UCL
T cell homeostasisISS:UniProtKB
Cellular Location
Mitochondrion
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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