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PPP1R1B

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

protein phosphatase 1 regulatory inhibitor subunit 1B

Function

Inhibitor of protein-phosphatase 1.

Biological Process

Behavioral response to cocaineIEA:Ensembl
Cellular response to cocaineIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Locomotory behaviorIEA:Ensembl
Negative regulation of female receptivityIEA:Ensembl
Negative regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:CAFA
Response to amphetamineIEA:Ensembl
Response to morphineIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Transcription, DNA-templatedIEA:Ensembl
Visual learningIEA:Ensembl

Cellular Location

Cytoplasm

PTM

Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.

Anti-PPP1R1B antibodies

Rat Anti-PPP1R1B Recombinant Antibody (7H163) (CBMAB-D0240-YC)

SDS

Target: PPP1R1B

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse, Rat

Clone: 7H163

Application*: E, WB, IH

Rabbit Anti-PPP1R1B Recombinant Antibody (7H17) (CBMAB-D0238-YC)

SDS

Target: PPP1R1B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat

Clone: 7H17

Application*: WB, IP, IH, IF

Rabbit Anti-PPP1R1B Recombinant Antibody (K.935.4) (CBMAB-D0237-YC)

SDS

Target: PPP1R1B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: K.935.4

Application*: IF, P, IP, WB

Rabbit Anti-PPP1R1B Recombinant Antibody (CBYCD-151) (CBMAB-D0235-YC)

SDS

Target: PPP1R1B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Pig

Clone: CBYCD-151

Application*: WB, IP, P, C, IC, F, IF

Mouse Anti-PPP1R1B Recombinant Antibody (2G6D9) (CBMAB-D0234-YC)

SDS

Target: PPP1R1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2G6D9

Application*: WB, F, E

Mouse Anti-PPP1R1B Recombinant Antibody (2A4G9) (CBMAB-D0233-YC)

SDS

Target: PPP1R1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2A4G9

Application*: WB, E

Mouse Anti-Ppp1r1b Recombinant Antibody (15/DARPP-32) (CBMAB-D2195-YC)

SDS

Target: PPP1R1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse, Rat

Clone: 15/DARPP-32

Application*: WB, IF

Rabbit Anti-PPP1R1B Recombinant Antibody (19A3) (CBMAB-D2194-YC)

SDS

Target: PPP1R1B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 19A3

Application*: WB, IP, P, IF

Mouse Anti-PPP1R1B Monoclonal Antibody (2A4G9) (CBMAB-0985-YC)

SDS

Target: PPP1R1B

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 2A4G9

Application*: E, WB

Mouse Anti-PPP1R1B Monoclonal Antibody (2G6D9) (CBMAB-0984-YC)

SDS

Target: PPP1R1B

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2G6D9

Application*: E, F, WB

Rabbit Anti-PPP1R1B Monoclonal Antibody (K.935.4) (CBMAB-0983-YC)

SDS

Target: PPP1R1B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: K.935.4

Application*: IF, P, IP, WB

Rabbit Anti-PPP1R1B Monoclonal Antibody (EP721Y) (CBMAB-0982-YC)

SDS

Target: PPP1R1B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EP721Y

Application*: IC, IF, P, IP, WB

Rabbit Anti-PPP1R1B Monoclonal Antibody (EP720Y) (CBMAB-0981-YC)

SDS

Target: PPP1R1B

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Pig

Clone: EP720Y

Application*: F, IC, IF, C, P, IP, WB

Mouse Anti-PPP1R1B Recombinant Antibody (1A3) (CBMAB-A6967-LY)

SDS

Target: PPP1R1B

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A3

Application*: WB, E

Mouse Anti-PPP1R1B Recombinant Antibody (3G11) (CBMAB-P2613-YC)

SDS

Target: PPP1R1B

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3G11

Application*: E, WB

Rat Anti-PPP1R1B Recombinant Antibody (141515) (CBMAB-P2611-YC)

SDS

Target: PPP1R1B

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 141515

Application*: P, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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