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Mouse Anti-PPP1R1B Recombinant Antibody (1A3) (CBMAB-A6967-LY)

The product is antibody recognizes PPP1R1B. The antibody 1A3 immunoassay techniques such as: WB, ELISA.
See all PPP1R1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A3
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
PPP1R1B (AAH01519, 1 a.a. ~ 168 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
protein phosphatase 1 regulatory inhibitor subunit 1B
Introduction
Midbrain dopaminergic neurons play a critical role in multiple brain functions, and abnormal signaling through dopaminergic pathways has been implicated in several major neurologic and psychiatric disorders. One well-studied target for the actions of dopamine is DARPP32. In the densely dopamine- and glutamate-innervated rat caudate-putamen, DARPP32 is expressed in medium-sized spiny neurons (Ouimet and Greengard, 1990 [PubMed 2191086]) that also express dopamine D1 receptors (Walaas and Greengard, 1984 [PubMed 6319627]). The function of DARPP32 seems to be regulated by receptor stimulation. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions (Halpain et al., 1990 [PubMed 2153935]). Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32 (Walaas and Greengard, 1984 [PubMed 6319627]); phosphorylated DARPP32 is a potent protein phosphatase-1 (see MIM 176875) inhibitor (Hemmings et al., 1984 [PubMed 6087160]). NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32 (Halpain et al., 1990 [PubMed 2153935]).[supplied by OMIM
Entrez Gene ID
84152
UniProt ID
Q9UD71
Alternative Names
DARPP-32; DARPP32; FLJ20940
Function
Inhibitor of protein-phosphatase 1.
Biological Process
Behavioral response to cocaineIEA:Ensembl
Cellular response to cocaineIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Locomotory behaviorIEA:Ensembl
Negative regulation of female receptivityIEA:Ensembl
Negative regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:CAFA
Response to amphetamineIEA:Ensembl
Response to morphineIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Transcription, DNA-templatedIEA:Ensembl
Visual learningIEA:Ensembl
Cellular Location
Cytoplasm
PTM
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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