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Rabbit Anti-PPP1R1B Recombinant Antibody (CBYCD-151) (CBMAB-D0235-YC)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Pig
Clone
CBYCD-151
Antibody Isotype
IgG
Application
WB, IP, IHC-P, IHC-Fr, ICC, FC, IF

Basic Information

Specificity
Human, Mouse, Rat, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
protein phosphatase 1 regulatory inhibitor subunit 1B
Introduction
PPP1R1B is a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, PPP1R1B may serve as a therapeutic target for neurologic and psychiatric disorders.
Entrez Gene ID
Human84152
Mouse19049
Rat360616
Pig100736966
UniProt ID
HumanQ9UD71
MouseQ60829
RatQ6J4I0
PigA0A5G2R4I7
Alternative Names
DARPP32; DARPP-32
Function
Inhibitor of protein-phosphatase 1.
Biological Process
Behavioral response to cocaineIEA:Ensembl
Cellular response to cocaineIEA:Ensembl
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Locomotory behaviorIEA:Ensembl
Negative regulation of female receptivityIEA:Ensembl
Negative regulation of phosphoprotein phosphatase activityManual Assertion Based On ExperimentIDA:CAFA
Response to amphetamineIEA:Ensembl
Response to morphineIEA:Ensembl
Signal transductionManual Assertion Based On ExperimentTAS:UniProtKB
Transcription, DNA-templatedIEA:Ensembl
Visual learningIEA:Ensembl
Cellular Location
Cytoplasm
PTM
Dopamine- and cyclic AMP-regulated neuronal phosphoprotein.
Phosphorylation of Thr-34 is required for activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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