PRLR

PRLR is a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor.
Full Name
PRLR
Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Biological Process
Activation of Janus kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Activation of transmembrane receptor protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Embryo implantationManual Assertion Based On ExperimentTAS:ProtInc
LactationManual Assertion Based On ExperimentTAS:ProtInc
Mammary gland alveolus developmentIEA:Ensembl
Mammary gland epithelial cell differentiationIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Oncostatin-M-mediated signaling pathwayIEA:GOC
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Prostate gland growthIEA:Ensembl
Receptor signaling pathway via JAK-STATIEA:Ensembl
Regulation of cell adhesionIEA:Ensembl
Regulation of epithelial cell differentiationIEA:Ensembl
Response to bacteriumIEA:Ensembl
Steroid biosynthetic process1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Isoform 7
Secreted
Involvement in disease
Multiple fibroadenomas of the breast (MFAB):
A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
Hyperprolactinemia (HPRL):
A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.
Topology
Extracellular: 25-234
Helical: 235-258
Cytoplasmic: 259-622
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Anti-PRLR antibodies

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Rabbit Anti-PRLR Recombinant Antibody (D4A9) (CBMAB-CP2088-LY)

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Target: PRLR
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4A9
Application*: WB, P
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (1E4) (CBMAB-A7070-LY)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1E4
Application*: WB, E
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (U5) (CBMAB-P2929-YC)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Cattle, Horse, Hamster, Rabbit, Sheep
Clone: U5
Application*: WB, F, P, C
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (T6) (CBMAB-P2928-YC)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: T6
Application*: WB, IH, P
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (ERSV8-1) (CBMAB-P2926-YC)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: ERSV8-1
Application*: IF, P
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (B6.2) (CBMAB-P2925-YC)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B6.2
Application*: WB, F, E, IC, IF, IP, P, C
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (CBYC-P637) (CBMAB-P2923-YC)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-P637
Application*: WB, N
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (CBYC-P636) (CBMAB-P2922-YC)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYC-P636
Application*: AG
Functional Assay
Datasheet SDS

Mouse Anti-PRLR Recombinant Antibody (1A2B1) (CBMAB-P2921-YC)

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Target: PRLR
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1A2B1
Application*: F, IC, IF, IH, IP, WB
Datasheet SDS

Human PRLR ELISA Kit (V2LY-0626-LY4191)

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Target: PRLR
Sensitivity: 0.022 ng/mL
Detection Range: 0.05-20 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Prlr ELISA Kit (V2LY-0626-LY2897)

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Target: Prlr
Sensitivity: 0.0021 ng/mL
Detection Range: 0.005-1 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Rat Prlr ELISA Kit (V2LY-0626-LY2533)

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Target: Prlr
Sensitivity: 0.0093 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Datasheet SDS

Rat Recombinant PRLR protein, His Tag (V2LY-0526-LY9561)

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Target: PRLR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-229
Tag: His Tag
Datasheet SDS

Mouse Recombinant PRLR protein, His Tag (V2LY-0526-LY8801)

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Target: PRLR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-229
Tag: His Tag
Datasheet SDS

Mouse Recombinant PRLR protein, His & hFc Tag (V2LY-0526-LY8800)

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Target: PRLR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-229
Tag: His & hFc Tag
Datasheet SDS

Human Recombinant PRLR protein, His Tag (V2LY-0526-LY6339)

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Target: PRLR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-234
Tag: His Tag
Datasheet SDS

Cynomolgus Recombinant PRLR protein, His Tag (V2LY-0526-LY1625)

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Target: PRLR
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-236
Tag: His Tag
Datasheet SDS

Human Anti-PRLR Recombinant Antibody (
1D3) (V2LY-0725-LY856)

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Target: PRLR
Host: Human
Antibody Isotype: IgG2
Specificity: Human, Mouse
Clone: 1D3
Application*: E
Datasheet SDS

PRLR Matched Antibody Pair (932) (APMAB-932LY)

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Target: PRLR
Specificity: Human
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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