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PRLR

PRLR is a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor.

Full Name

PRLR

Function

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

Biological Process

Activation of Janus kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Activation of transmembrane receptor protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Embryo implantationManual Assertion Based On ExperimentTAS:ProtInc
LactationManual Assertion Based On ExperimentTAS:ProtInc
Mammary gland alveolus developmentIEA:Ensembl
Mammary gland epithelial cell differentiationIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Oncostatin-M-mediated signaling pathwayIEA:GOC
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Prostate gland growthIEA:Ensembl
Receptor signaling pathway via JAK-STATIEA:Ensembl
Regulation of cell adhesionIEA:Ensembl
Regulation of epithelial cell differentiationIEA:Ensembl
Response to bacteriumIEA:Ensembl
Steroid biosynthetic process1 PublicationNAS:UniProtKB

Cellular Location

Membrane
Isoform 7
Secreted

Involvement in disease

Multiple fibroadenomas of the breast (MFAB):
A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
Hyperprolactinemia (HPRL):
A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.

Topology

Extracellular: 25-234
Helical: 235-258
Cytoplasmic: 259-622

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Anti-PRLR antibodies

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Rabbit Anti-PRLR Recombinant Antibody (D4A9) (CBMAB-CP2088-LY)

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Target: PRLR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D4A9

Application*: WB, P

Mouse Anti-PRLR Recombinant Antibody (1E4) (CBMAB-A7070-LY)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1E4

Application*: WB, E

Mouse Anti-PRLR Recombinant Antibody (U5) (CBMAB-P2929-YC)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Pig, Cattle, Horse, Hamster, Rabbit, Sheep

Clone: U5

Application*: WB, F, P, C

Mouse Anti-PRLR Recombinant Antibody (T6) (CBMAB-P2928-YC)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: T6

Application*: WB, IH, P

Mouse Anti-PRLR Recombinant Antibody (ERSV8-1) (CBMAB-P2926-YC)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: ERSV8-1

Application*: IF, P

Mouse Anti-PRLR Recombinant Antibody (B6.2) (CBMAB-P2925-YC)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: B6.2

Application*: WB, F, E, IC, IF, IP, P, C

Mouse Anti-PRLR Recombinant Antibody (CBYC-P637) (CBMAB-P2923-YC)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYC-P637

Application*: WB, N

Mouse Anti-PRLR Recombinant Antibody (CBYC-P636) (CBMAB-P2922-YC)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Rat

Clone: CBYC-P636

Application*: AG

Functional Assay

Mouse Anti-PRLR Recombinant Antibody (1A2B1) (CBMAB-P2921-YC)

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Target: PRLR

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1A2B1

Application*: F, IC, IF, IH, IP, WB

Human Anti-PRLR Recombinant Antibody (
1D3) (V2LY-0725-LY856)

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Target: PRLR

Host: Human

Antibody Isotype: IgG2

Specificity: Human, Mouse

Clone: 1D3

Application*: E

PRLR Matched Antibody Pair (932) (APMAB-932LY)

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Target: PRLR

Specificity: Human

More Infomation

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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