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Mouse Anti-PRLR Recombinant Antibody (B6.2) (CBMAB-P2925-YC)

Provided herein is a Mouse monoclonal antibody against Human Prolactin Receptor. The antibody can be used for immunoassay techniques, such as WB, FC, ELISA, ICC, IF, IP, IHC-P, IHC-Fr.
See all PRLR antibodies
Published Data
Fig.1 Immunohistochemistry of PRL-R revealed a strong positivity in metastatic pineal lymphomas.
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Fig.2 Western blot analysis revealed PRL-R expression in the pineal lymphoma.
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Fig.3 Immunohistochemical demonstration of PRLR in the invasive ductal carcinoma.
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Fig.4 Histological sections of atypical lobular hyperplasia (ALH).
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Fig.5 Prolactin receptor (PRLR)+ immunohistochemistry in gynaecomastia.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
B6.2
Antibody Isotype
IgG1, κ
Application
WB, FC, ELISA, ICC, IF, IP, IHC-P, IHC-Fr

Basic Information

Immunogen
Semi-purified human prolactin receptor
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PRLR
Introduction
PRLR is a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor.
Entrez Gene ID
5618
UniProt ID
P16471
Alternative Names
MFAB; hPRLrI; HPRL
Function
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.
Biological Process
Activation of Janus kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Activation of transmembrane receptor protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Embryo implantationManual Assertion Based On ExperimentTAS:ProtInc
LactationManual Assertion Based On ExperimentTAS:ProtInc
Mammary gland alveolus developmentIEA:Ensembl
Mammary gland epithelial cell differentiationIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Oncostatin-M-mediated signaling pathwayIEA:GOC
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Prostate gland growthIEA:Ensembl
Receptor signaling pathway via JAK-STATIEA:Ensembl
Regulation of cell adhesionIEA:Ensembl
Regulation of epithelial cell differentiationIEA:Ensembl
Response to bacteriumIEA:Ensembl
Steroid biosynthetic process1 PublicationNAS:UniProtKB
Cellular Location
Membrane
Isoform 7
Secreted
Involvement in disease
Multiple fibroadenomas of the breast (MFAB):
A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
Hyperprolactinemia (HPRL):
A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.
Topology
Extracellular: 25-234
Helical: 235-258
Cytoplasmic: 259-622
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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