Rat Recombinant PRLR protein, His Tag (V2LY-0526-LY9561)

Name: Rat Recombinant PRLR protein, His Tag
SKU: V2LY-0526-LY9561
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Rat

Tag

His Tag

Protein Construction

This product is Rat Recombinant PRLR protein, His Tag consist of Amino Acid: 1-229 and predicts a molecular mass of 26 kDa.

Molecule Mass

26 kDa

Sequence

Amino Acid: 1-229

Species

Rat

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>97% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

PRLR

Function

This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.

Biological Process

Activation of Janus kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Activation of transmembrane receptor protein tyrosine kinase activityManual Assertion Based On ExperimentIDA:UniProtKB
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Embryo implantationManual Assertion Based On ExperimentTAS:ProtInc
LactationManual Assertion Based On ExperimentTAS:ProtInc
Mammary gland alveolus developmentIEA:Ensembl
Mammary gland epithelial cell differentiationIEA:Ensembl
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Oncostatin-M-mediated signaling pathwayIEA:GOC
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Prostate gland growthIEA:Ensembl
Receptor signaling pathway via JAK-STATIEA:Ensembl
Regulation of cell adhesionIEA:Ensembl
Regulation of epithelial cell differentiationIEA:Ensembl
Response to bacteriumIEA:Ensembl
Steroid biosynthetic process1 PublicationNAS:UniProtKB

Cellular Location

Membrane
Isoform 7
Secreted

Involvement in disease

Multiple fibroadenomas of the breast (MFAB):
A benign breast disease marked by lobuloalveolar growth with abnormally high proliferation of the epithelium, and characterized by the presence of more than 3 fibroadenomas in one breast. Fibroadenomas are adenomas containing fibrous tissue.
Hyperprolactinemia (HPRL):
A disorder characterized by increased levels of prolactin in the blood not associated with gestation or the puerperium. HPRL may result in infertility, hypogonadism, and galactorrhea.

Topology

Extracellular: 25-234
Helical: 235-258
Cytoplasmic: 259-622

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant PRLR protein, His Tag (CAT#: V2LY-0526-LY1625)

Human Recombinant PRLR protein, His Tag (CAT#: V2LY-0526-LY6339)

Mouse Recombinant PRLR protein, His & hFc Tag (CAT#: V2LY-0526-LY8800)

Mouse Recombinant PRLR protein, His Tag (CAT#: V2LY-0526-LY8801)

PRLR Matched Antibody Pair (932) (CAT#: APMAB-932LY)

Antibody Pairs

PRLR Matched Antibody Pair (932) (CAT#: APMAB-932LY)

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Mouse Anti-PRLR Recombinant Antibody (1E4) (CAT#: CBMAB-A7070-LY)

Mouse Anti-PRLR Recombinant Antibody (T6) (CAT#: CBMAB-P2928-YC)

Mouse Recombinant PRLR protein, His & hFc Tag (CAT#: V2LY-0526-LY8800)

Mouse Anti-PRLR Recombinant Antibody (B6.2) (CAT#: CBMAB-P2925-YC)

Mouse Anti-PRLR Recombinant Antibody (1A2B1) (CAT#: CBMAB-P2921-YC)

Mouse Anti-PRLR Recombinant Antibody (CBYC-P636) (CAT#: CBMAB-P2922-YC)

Mouse Recombinant PRLR protein, His Tag (CAT#: V2LY-0526-LY8801)

Mouse Anti-PRLR Recombinant Antibody (ERSV8-1) (CAT#: CBMAB-P2926-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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