PTGES2

The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq]

Full Name

PTGES2

Function

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783).
The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783).
In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity).

Biological Process

Cyclooxygenase pathwayTAS:Reactome
Glutathione metabolic processIEA:InterPro
Lipid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedIEA:Ensembl
SecretionIEA:Ensembl

Cellular Location

Golgi apparatus membrane
Prostaglandin E synthase
Cytoplasm, perinuclear region
Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.

Topology

Lumenal: 1-57
Helical: 58-74
Cytoplasmic: 75-377

PTM

Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme.