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Mouse Anti-PTGES2 Recombinant Antibody (2C3) (CBMAB-P3327-YC)

Provided herein is a Mouse monoclonal antibody against Human Prostaglandin E synthase 2. The antibody can be used for immunoassay techniques, such as IF, IHC-P, WB.
See all PTGES2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C3
Antibody Isotype
IgG2a
Application
IF, IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PTGES2
Introduction
PTGES2 is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE).
Entrez Gene ID
80142
UniProt ID
Q9H7Z7
Alternative Names
GBF-1; GBF1; C9orf15; mPGES-2; PGES2
Function
Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2) (in vitro) (PubMed:12804604, PubMed:18198127, PubMed:17585783).
The biological function and the GSH-dependent property of PTGES2 is still under debate (PubMed:18198127, PubMed:17585783).
In vivo, PTGES2 could form a complex with GSH and heme and would not participate in PGE2 synthesis but would catalyze the degradation of prostaglandin E2 H2 (PGH2) to 12(S)-hydroxy-5(Z),8(E),10(E)-heptadecatrienoic acid (HHT) and malondialdehyde (MDA) (PubMed:17585783) (By similarity).
Biological Process
Cyclooxygenase pathwayTAS:Reactome
Glutathione metabolic processIEA:InterPro
Lipid metabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription, DNA-templatedIEA:Ensembl
SecretionIEA:Ensembl
Cellular Location
Golgi apparatus membrane
Prostaglandin E synthase
Cytoplasm, perinuclear region
Synthesized as a Golgi membrane-bound protein, which is further cleaved into the predominant soluble truncated form. The truncated form is cytoplasmic and is enriched in the perinuclear region.
Topology
Lumenal: 1-57
Helical: 58-74
Cytoplasmic: 75-377
PTM
Synthesized as a Golgi membrane-associated protein, and the proteolytic removal of the N-terminal hydrophobic domain leads to the formation of a mature cytosolic enzyme.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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