PTP4A3

PTP4A3 is a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis.

Protein tyrosine phosphatase type IVA, member 3

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Cellular response to leukemia inhibitory factorIEA:Ensembl
Endothelial cell migrationManual Assertion Based On ExperimentIMP:MGI
Notch signaling pathwayIEA:Ensembl
Positive regulation of establishment of protein localizationManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of vascular permeabilityIEA:Ensembl
Protein dephosphorylationIEA:InterPro
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:CAFA
Regulation of vascular endothelial growth factor signaling pathwayIEA:Ensembl

Cell membrane
Early endosome

Farnesylated. Farnesylation is required for membrane targeting (By similarity).