Mouse Anti-PTP4A3 Recombinant Antibody (CBYC-P774) (CBMAB-P3406-YC)

Name: Mouse Anti-PTP4A3 Recombinant Antibody (CBYC-P774)
SKU: CBMAB-P3406-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBYC-P774

Application

Immunogen

E. coli-derived Recombinant human PRL-3, Ala2-Met173

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG2b

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS with trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Protein tyrosine phosphatase type IVA, member 3

Introduction

PTP4A3 is a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis.

Entrez Gene ID

Human	11156
Mouse	19245
Rat	362930

UniProt ID

Human	O75365
Mouse	Q9D658
Rat	B0K032

Alternative Names

PRL3; PRL-R; PRL-3

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.

Biological Process

Cellular response to leukemia inhibitory factorIEA:Ensembl
Endothelial cell migrationManual Assertion Based On ExperimentIMP:MGI
Notch signaling pathwayIEA:Ensembl
Positive regulation of establishment of protein localizationManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of vascular permeabilityIEA:Ensembl
Protein dephosphorylationIEA:InterPro
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:CAFA
Regulation of vascular endothelial growth factor signaling pathwayIEA:Ensembl

Cellular Location

Cell membrane
Early endosome

PTM

Farnesylated. Farnesylation is required for membrane targeting (By similarity).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Human PTP4A3 ELISA Kit (CAT#: V2LY-0626-LY3072)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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