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Mouse Anti-PTP4A3 Recombinant Antibody (CBYC-P775) (CBMAB-P3407-YC)

Provided herein is a Mouse monoclonal antibody against Human Protein tyrosine phosphatase type IVA, member 3. The antibody can be used for immunoassay techniques, such as WB, ICC, IHC-P, IHC-Fr, ELISA.
See all PTP4A3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-P775
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA

Basic Information

Immunogen
Protein Tyrosine Phosphatase Type IVA 3
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.4, 0.02% sodium azide, 50% glycerol
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Protein tyrosine phosphatase type IVA, member 3
Introduction
PTP4A3 is a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis.
Entrez Gene ID
11156
UniProt ID
O75365
Alternative Names
PRL3; PRL-R; PRL-3
Function
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II.
Biological Process
Cellular response to leukemia inhibitory factorIEA:Ensembl
Endothelial cell migrationManual Assertion Based On ExperimentIMP:MGI
Notch signaling pathwayIEA:Ensembl
Positive regulation of establishment of protein localizationManual Assertion Based On ExperimentIMP:CAFA
Positive regulation of NIK/NF-kappaB signalingManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of vascular permeabilityIEA:Ensembl
Protein dephosphorylationIEA:InterPro
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:CAFA
Regulation of vascular endothelial growth factor signaling pathwayIEA:Ensembl
Cellular Location
Cell membrane
Early endosome
PTM
Farnesylated. Farnesylation is required for membrane targeting (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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