PXN

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445). [provided by RefSeq, Aug 2011]
Full Name
Paxillin
Function
Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).
Biological Process
Cell adhesion1 PublicationNAS:ProtInc
Cell-matrix adhesionIEA:InterPro
Cellular response to reactive oxygen speciesManual Assertion Based On ExperimentIEP:BHF-UCL
Endothelial cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Growth hormone receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of stress fiber assemblyManual Assertion Based On ExperimentIMP:BHF-UCL
Signal complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Transforming growth factor beta receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cytoplasm, cytoskeleton
Cell junction, focal adhesion
Cytoplasm, cell cortex
Colocalizes with integrins at the cell periphery. Colocalize with PXN to membrane ruffles and the leading edge of migrating cells (PubMed:23128389).
PTM
Phosphorylated by MAPK1/ERK2 (By similarity).
Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (PubMed:23128389).
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Anti-PXN antibodies

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Rabbit Anti-PXN (phosphorylated Tyr118) Recombinant Antibody (CBNH-184) (CBMAB-R4509-CN)

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Target: PXN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-184
Application*: E, WB
Datasheet SDS

Mouse Anti-PXN Recombinant Antibody (CBYC-P806) (CBMAB-P3560-YC)

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Target: PXN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYC-P806
Application*: IF, IH, IP, WB
Datasheet SDS

Mouse Anti-PXN Recombinant Antibody (PXC-10) (CBMAB-P3559-YC)

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Target: PXN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Hamster, Cattle
Clone: PXC-10
Application*: IC, IF, WB
Datasheet SDS

Mouse Anti-PXN Recombinant Antibody (PAX-14) (CBMAB-P3558-YC)

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Target: PXN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Chicken
Clone: PAX-14
Application*: IP
Datasheet SDS

Mouse Anti-PXN Recombinant Antibody (9H169) (CBMAB-P3557-YC)

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Target: PXN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 9H169
Application*: IC, WB
Datasheet SDS

Mouse Anti-PXN Recombinant Antibody (5H11) (CBMAB-P3556-YC)

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Target: PXN
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5H11
Application*: IF, P, IP, WB
Datasheet SDS

Mouse Anti-PXN Recombinant Antibody (349/Paxillin) (CBMAB-P3555-YC)

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Target: PXN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 349/Paxillin
Application*: IF
Datasheet SDS

Rabbit Anti-PXN Recombinant Antibody (RM256) (CBMAB-BR422LY)

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Target: PXN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: RM256
Application*: WB
Datasheet SDS

Rabbit Anti-PXN Recombinant Antibody (D9G12) (CBMAB-CP1880-LY)

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Target: PXN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D9G12
Application*: WB, IP
Datasheet SDS

Rabbit Anti-PXN Recombinant Antibody (CBNH-091) (CBMAB-R4416-CN)

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Target: PXN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBNH-091
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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