RAB11FIP4

The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]

Full Name

RAB11 Family Interacting Protein 4

Function

Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.

Biological Process

Biological Process endocytic recyclingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Endosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Recycling endosome membrane
Cleavage furrow
Midbody
Cytoplasmic vesicle
Recruited to the cleavage furrow and the midbody during cytokinesis.