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Mouse Anti-RAB11FIP4 Recombinant Antibody (13B5) (CBMAB-R0701-CN)

This product is a Mouse antibody that recognizes RAB11FIP4. The antibody 13B5 can be used for immunoassay techniques such as: WB, IHC.
See all RAB11FIP4 antibodies
Published Data
Fig. 1 Western blot analysis of protein interactions and lysate proteins resulting from Co-IP analysis of Rab11-FIP4, Rab11 and IGF1R.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
13B5
Antibody Isotype
IgG2b
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to aa. 91-177 of human RAB11FIP4 (NP_116321) produced in E.coli
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.3, 1% BSA, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
1 mg/mL

Target

Full Name
RAB11 Family Interacting Protein 4
Introduction
The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
Entrez Gene ID
84440
UniProt ID
Q86YS3
Alternative Names
RAB11 Family Interacting Protein 4; RAB11 Family Interacting Protein 4 (Class II); Arfophilin-2; RAB11-FIP4; FIP4-Rab11; Rab11 Family-Interacting Protein 4; KIAA1821; ARFO2;
Function
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6.
Biological Process
Biological Process endocytic recyclingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endosome
Cytoplasm, cytoskeleton, spindle
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Recycling endosome membrane
Cleavage furrow
Midbody
Cytoplasmic vesicle
Recruited to the cleavage furrow and the midbody during cytokinesis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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