RAET1E

Members of the RAET1 family, such as RAET1E, are major histocompatibility complex (MHC) class I-related genes located within a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteins contain MHC class I-like alpha-1 and alpha-2 domains. RAET1E and RAET1G (MIM 609244) differ from the other RAET1 proteins (e.g., RAET1I, or ULBP1; MIM 605697) in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM
Full Name
retinoic acid early transcript 1E
Function
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.
Biological Process
Biological Process natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Isoform 4
Secreted
Topology
Extracellular: 31-225
Helical: 226-248
Cytoplasmic: 249-263
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Anti-RAET1E antibodies

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Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D11
Application*: E
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 79/6
Application*: E, F, IF, IP, FN, WB
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 79/6/13/16
Application*: WB, IP, E, N, FC, IF
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: RAET1E 79/6
Application*: FC
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: RAET1E 119/6
Application*: FC
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 709116
Application*: FC
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBWJN-1650
Application*: F, P, WB
Target: RAET1E
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJN-1649
Application*: F, N
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 50/3
Application*: E, F, IF, IP, N, WB
Target: RAET1E
Host: Rat
Specificity: Mouse
Clone: 15H135
Application*: F, N
Target: RAET1E
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 119/6
Application*: E, F, IF, IP, N, WB
Target: RAET1E
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 205001
Application*: F, N, MC
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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